3-D implants save three infants, early dino flew like a bat, & more

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Latest News and Headlines 29 April 2015

Senate advances secret science bill, setting up possible showdown with White House

Updated: Sexist peer review elicits furious Twitter response, PLOS apology

Three-dimensional printed throat implants save three infants

Early dinosaur may have flown like a bat

Artificial light may alter underwater ecosystems

Leafcutter ants use chemical warfare to keep fungus at bay

Bird accents change with elevation

U.S. won’t drop census questions on college major and marital history

Ancient megadrought entombed dodos in poisonous fecal cocktail

Journal responds to controversy over embryo gene-editing paper

Salty water lurks beneath Antarctica

Will a kinder, gentler census survey placate congressional foes?

Heartland danger zones emerge on new U.S. earthquake hazard map

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Latest from Science News: Pluto’s landscapes come into view as New Horizons closes in

Latest from Science News 04/30/2015 View in browser Become a Subscribing Member» Science Ticker Pluto’s landscapes come into view as New Horizons closes in BY Christopher Crockett, Apr 29, 2015 06:28 pm The New Horizons spacecraft sees surface markings and a possible polar cap on Pluto as it closes in for a July encounter. Read More Read More» Growth Curve How baby cries bore into mom’s brain BY Laura Sanders, Apr 29, 2015 04:43 pm Mouse moms’ brains are sculpted by pups’ pleas for help, which make her into a better mother. Read More Read More» Science Ticker Rare fossils expand evolutionary history of sperm whales BY Helen Thompson, Apr 29, 2015 04:14 pm A pygmy fossil unearthed in Panama reveals that the organ the whales use to produce sound and echolocate shrunk over time. Read More Read More» More Headlines from Science News Wild Things A protein battle underlies the beauty of orchids The petal-and-lip shape that draws pollinators to orchids results from a competition between two protein complexes, a new study finds. Read More By Sarah Zielinski, Apr 28, 2015 04:00 pm News Childhood bullying leads to long-term mental health problems U.S., British data raise bullying’s profile as a long-term mental health hazard for kids. Read More By Bruce Bower, Apr 28, 2015 03:00 pm Feature The Martian Diaries Curiosity has explored Mars for over two and a half years. What if NASA’s rover kept a scrapbook? Read More By Alexandra Witze, Apr 28, 2015 01:19 pm News Stronger quakes could strike other segments of Nepal fault The magnitude 7.8 earthquake that struck Nepal’s capital city could be overshadowed by larger future earthquakes along the Himalayas, scientists say. Read More By Thomas Sumner, Apr 28, 2015 12:07 pm Science Stats Just 1 percent of Amazon’s trees hold half of its carbon Roughly 1 percent of tree species in the Amazon rainforest account for half of the jungle’s carbon storage. Read More By Thomas Sumner, Apr 28, 2015 11:00 am News Hidden water found deep beneath Antarctica desert valley New imaging reveals liquid water network beneath Antarctica’s McMurdo Dry Valleys that could support microbial life. Read More By Thomas Sumner, Apr 28, 2015 11:00 am Scicurious For the blind, hearing the way forward can be a tradeoff Many blind people have enhanced hearing. A new study shows that the ability to hear your way forward might come at the cost of hearing up and down. Read More By Bethany Brookshire, Apr 28, 2015 07:41 am Privacy Policy | Update Email Preferences | Unsubscribe from All SSP Newsletters | Contact Us Facebook | Twitter | Vimeo | Google+ Society for Science & the Public • 1719 N Street, N.W. Washington, DC 20036 • Copyright © 2015

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Sci Transl Med Table of Contents for 29 April 2015; Vol. 7, No. 285

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Sponsored by Waters Corporation Science Translational Medicine Table of Contents   04/29/15 Volume 7, Issue 285 Attend GTCbio’s European Pharma Summit to network with the best in drug discovery (5-8 May, 2015 Berlin, Germany). Register today! Join Science Translational Medicine in Stockholm, Sweden, May 7-8, for Days of Molecular Medicine 2015 Last chance to register for Bridging Biomedical Worlds “From Neural Circuitry to Neurotechnology” in Tokyo. <!– Science Translational Medicine welcomes our 2015 Associate Scientific Advisors. –> <!– The focus of this week’s issue is cancer to coincide with the AACR annual meeting –> In this week’s issue: Research Articles COMPUTATIONAL MODELING Trauma in silico: Individual-specific mathematical models and virtual clinical populations David Brown et al. A mathematical model of the human response to trauma replicates individual patient outcomes but predicts unexpected results in populations. METABOLOMICS Urinary metabolic signatures of human adiposity Paul Elliott et al. In a large-scale population-based metabolic phenotyping study, diverse sets of urinary metabolites, including gut microbial co-metabolites, were reproducibly associated with human adiposity. IMMUNOTHERAPY CMV-specific T cells generated from naïve T cells recognize atypical epitopes and may be protective in vivo Patrick J. Hanley et al. CMV-specific T cells, derived from the naïve population, recognize different epitopes of CMV than do memory-derived T cells and may be functional and protective in vivo. BIOENGINEERING Mitigation of tracheobronchomalacia with 3D-printed personalized medical devices in pediatric patients Robert J. Morrison et al. Patient-specific, image-based design coupled with 3D biomaterial printing produced personalized implants for treatment of collapsed airways in patients with tracheobronchomalacia. HYPERTENSION Arterial microanatomy determines the success of energy-based renal denervation in controlling hypertension Abraham R. Tzafriri et al. Local tissue anatomy determines the success of renal nerve ablation and explains its variable effects on blood pressure. Editorial GRADUATE EDUCATION Transforming training to reflect the workforce Ambika Mathur et al. Twenty-first century training programs seek to provide the “BEST” graduate education for our future biomedical workforce. Focus POLICY American medical education at a crossroads Arthur M. Feldman et al. New research-deficient systems of medical education could diminish the translation of biomedical advances to patients. HYPERTENSION Renal denervation: Not as easy as it looks Murray Esler Renal sympathetic denervation in hypertensive patients is less effective than anticipated, owing to radio frequency energy being applied to a part of the renal artery where the nerves are at the greatest distance from the aortic lumen, and to distortion of energy distribution and temperature gradients by regional tissue anatomical variations (Tzafriri et al., this issue). Editors’ Choice SLEEP Sleep well, breathe well, age well Yo-El Ju Sleep-disordered breathing hastens cognitive decline by a decade, but positive airway pressure treatment may offset this effect. IMMUNOTHERAPY Checkpoint inhibitors continue to check out Alexander Marson INFLAMMATION Behold morphing monocytes at sites of liver damage Tanya J. Shaw Classical proinflammatory monocytes transition to a pro-repair phenotype during repair of sterile tissue damage in the liver. EPIGENETICS Childhood memory Masako Suzuki Epigenetic profile maturation in blood lymphocytes appears to occur during early childhood development in human females.     About the cover Also Online: Current Issue Information for Authors My Science Translational Medicine Recommend to Your Library Sponsored by Waters Corporation

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A U.S. earthquake hazard map, salty water under Antarctica, & more

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Latest News and Headlines 28 April 2015

Journal responds to controversy over embryo gene-editing paper

Salty water lurks beneath Antarctica

Will a kinder, gentler census survey placate congressional foes?

Heartland danger zones emerge on new U.S. earthquake hazard map

Greek government raids research funds to pay public salaries

Tom and Jerry syndrome causes seizures in old cats

Our favorite #upwardfacingdog photos: More of your submissions so far

Misleading sugar structures produce bitter result for protein sleuths

Gene activation therapy prevents liver damage in mice

T. rex cousin was early convert to vegetarianism

Nepal earthquake may herald more Himalayan temblors

Chinese paper on embryo engineering splits scientific community

Top stories: The vampire squid’s unusual sex life, 170-year-old champagne, and Yellowstone’s supervolcano

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Science Signaling Table of Contents for 28 April 2015; Volume 8, Issue 374

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Sponsored by the Science/AAAS Custom Publishing Office Watch Previously Recorded Webinars from Science/AAAS View our collection of over 50 webinars on webinar.sciencemag.org and learn how today’s research is shaping tomorrow’s discoveries. Featuring presentations from world renowned experts on a broad range of topics, including Noncoding RNAs, Imaging, Apoptosis, qPCR, Next-Gen Sequencing, and Stem Cell Research, the webinars are a tremendous learning tool that include previously recorded question and answer segments. Watch Science Webinars today at webinar.sciencemag.org. Science Signaling Table of Contents   04/28/15 Volume 8, Issue 374 Attend GTCbio’s European Pharma Summit to network with the best in drug discovery [5-8 May 2015, Berlin, Germany]: Register today!<!– –> In this week’s issue: Research Articles Developmental Neuroscience Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation Kristina B. Emdal et al. Proteomic analysis of neurotrophin signaling identifies an inhibitory E3 ubiquitin ligase. Research Resources Cellular Metabolism Dynamic phosphoproteomics reveals TORC1-dependent regulation of yeast nucleotide and amino acid biosynthesis Ana Paula Oliveira et al. The effect of phosphorylation on metabolic enzyme activity could be inferred by correlating phosphoproteomics and metabolomics data. Stress Signaling In vivo imaging of the spatiotemporal activity of the eIF2α-ATF4 signaling pathway: Insights into stress and related disorders Cédric Chaveroux et al. A transgenic mouse model enables analysis of the involvement of a stress signaling pathway in liver fibrosis. Reviews Immunology Redundant and specialized roles for diacylglycerol kinases α and ζ in the control of T cell functions Isabel Mérida et al. Two isoforms of the enzyme that attenuates signaling by the second messenger diacylglycerol regulate multiple properties of T lymphocytes. Editors’ Choice Cancer The stroma gives tumors a dose of drug tolerance Leslie K. Ferrarelli Blocking the kinase FAK may prevent fibroblasts from enabling resistance to BRAF inhibitors in melanomas. Cell Migration Intracellular pH gradient guides cells Annalisa M. VanHook An extracellular chemokine gradient drives formation of an intracellular pH gradient that guides directional cell migration. Pharmacology Can a cough suppressant treat diabetes? Sudhakaran Prabakaran Inhibiting the glutamate receptor NMDAR in pancreatic β cells improves glucose tolerance in type 2 diabetes. Hippo Signaling Keeping cells from getting Hippo-sized under energy stress Wei Wong The transcriptional coactivator YAP is inhibited by AMPK-mediated phosphorylation during energy stress. Cell Biology G protein activation at the Golgi Annalisa M. VanHook GIV regulates both heterotrimeric and monomeric G protein signaling at the Golgi. Immunology Immunotherapy according to GARP Nancy R. Gough Monoclonal antibodies that inhibit human Treg function may be used therapeutically in cancer or infections. Immunology Interfering with viral neuroinvasion Orla Smith Interferon-λ signaling tightens the blood-brain barrier, limiting West Nile virus infection of the central nervous system. Calcium Signaling Calcilytics may help asthmatics breathe easier Angela Colmone Calcilytics reduce airway hyperresponsiveness and inflammation and may represent effective asthma therapeutics. Immunology A genetic cause for severe influenza Kristen L. Mueller A mutation that reduces antiviral interferons underlies certain cases of severe influenza in children. Neuroscience SARM1-driven axon degeneration L. Bryan Ray A critical role is elucidated for destruction of a metabolic cofactor in neuronal degeneration. About the cover Also Online: Current Issue Table of Contents Science Signaling Homepage My Science Signaling Information for Authors Recommend to Your Library Sponsored by the Science/AAAS Custom Publishing Office Watch Previously Recorded Webinars from Science/AAAS View our collection of over 50 webinars on webinar.sciencemag.org and learn how today’s research is shaping tomorrow’s discoveries. Featuring presentations from world renowned experts on a broad range of topics, including Noncoding RNAs, Imaging, Apoptosis, qPCR, Next-Gen Sequencing, and Stem Cell Research, the webinars are a tremendous learning tool that include previously recorded question and answer segments. Watch Science Webinars today at webinar.sciencemag.org.

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Gene activation therapy, Himalayan earthquakes, & more

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Latest News and Headlines 27 April 2015

Greek government raids research funds to pay public salaries

Tom and Jerry syndrome causes seizures in old cats

Our favorite #upwardfacingdog photos: More of your submissions so far

Misleading sugar structures produce bitter result for protein sleuths

Gene activation therapy prevents liver damage in mice

T. rex cousin was early convert to vegetarianism

Nepal earthquake may herald more Himalayan temblors

Chinese paper on embryo engineering splits scientific community

Top stories: The vampire squid’s unusual sex life, 170-year-old champagne, and Yellowstone’s supervolcano

Eagle versus porcupine: Camera snaps a painful face-off

Breast cancer drug may help men with prostate cancer

Podcast: Vampire squids, isolated tribes, and more

How to predict an avalanche with radar and GPS

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Latest from Science News: Brain on display

Latest from Science News 04/28/2015 View in browser Become a Subscribing Member» The Science Life Brain on display BY Laura Sanders, Apr 27, 2015 04:06 pm In her online videos, Nancy Kanwisher goes where few other neuroscientists go. Read More Read More» Science Ticker Woolly mammoth DNA shows toll of low diversity BY Helen Thompson, Apr 27, 2015 01:39 pm A new sequencing analysis of two woolly mammoth genomes reveals evidence of genetic decline due to isolation and inbreeding just prior to extinction. Read More Read More» News Warming’s role in extreme weather quantified BY Beth Mole, Apr 27, 2015 11:00 am Scientists calculate how much to blame human-driven climate change for extreme high temperatures and heavy rainfall. Read More Read More» More Headlines from Science News Science Ticker City- and country-dwelling microbes aren’t so different A new study reveals the microbial communities in our nation’s dust. Read More By Bethany Brookshire, Apr 24, 2015 03:29 pm News Ritual cannibalism occurred in England 14,700 years ago Human bones show signs of ritual cannibalism in England 14,700 years ago. Read More By Bruce Bower, Apr 24, 2015 01:39 pm Culture Beaker Sometimes it’s best to feed the trolls There are people behind malicious comments on the Internet, and sometimes engaging with them can change their behavior, data suggest. Read More By Rachel Ehrenberg, Apr 24, 2015 12:43 pm Science Ticker To reduce stress and anxiety, make yourself invisible We may not be able to make people invisible, but researchers have discerned its effect on the human mind in a new study. Read More By Helen Thompson, Apr 24, 2015 10:56 am Say What? Lit-up gas clouds hint at galaxies’ violent pasts Voorwerpjes, tendrils of gas that orbit galaxies, continue to glow tens of thousands of years after being blasted with ultraviolet radiation. Read More By Christopher Crockett, Apr 24, 2015 08:00 am News Astronomers celebrating Hubble’s past focus on its future Astronomers celebrate the 25th anniversary of the Hubble Space Telescope by reflecting on its diversity and looking ahead to the future. Read More By Christopher Crockett, Apr 24, 2015 06:00 am Scicurious A peer-reviewed study finds value in peer-reviewed research The best scoring peer-reviewed grants are associated with more papers and patents, a new study finds. But whether peer review is the best system is another question entirely. Read More By Bethany Brookshire, Apr 23, 2015 06:56 pm Privacy Policy | Update Email Preferences | Unsubscribe from All SSP Newsletters | Contact Us Facebook | Twitter | Vimeo | Google+ Society for Science & the Public • 1719 N Street, N.W. Washington, DC 20036 • Copyright © 2015

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New avalanche radar, breast cancer drug targets prostate cancer, & porcupine face-offs!

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Latest News and Headlines 24 April 2015

Top stories: The vampire squid’s unusual sex life, 170-year-old champagne, and Yellowstone’s supervolcano

Eagle versus porcupine: Camera snaps a painful face-off

Breast cancer drug may help men with prostate cancer

Podcast: Vampire squids, isolated tribes, and more

How to predict an avalanche with radar and GPS

Two huge magma chambers spied beneath Yellowstone National Park

Thirty thousand square kilometers of land lost to oil and gas development

Stripped and cast out, the universes loneliest galaxies

Sophisticated tools may have spelled doom for Neandertals

Technique aims to cut disease-causing mutations out of eggs and embryos

Cosmic rays could reveal secrets of lightning on Earth

Oil and gas operations could trigger large earthquakes

U.S. House panel would slash Department of Energys applied research

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Editor’s picks: Hubble telescope looks to the future, when mom is dinner, cave find hints at cannibalism, landscaping that benefits birds, and more

Science News Editor’s Picks 04/26/15 View in browser Become a Subscribing Member » It's Alive When mom serves herself as dinner By Susan Milius For this spider, extreme motherhood ends with a fatal family feast. Read More Read More» News Astronomers celebrating Hubble’s past focus on its future By Christopher Crockett Astronomers celebrate the 25th anniversary of the Hubble Space Telescope by reflecting on its diversity and looking ahead to the future.  Read More Read More» News Ritual cannibalism occurred in England 14,700 years ago By Bruce Bower Human bones show signs of ritual cannibalism in England 14,700 years ago. Read More Read More» News Bees may like neonicotinoids, but some may be harmed By Susan Milius Two high-profile tests raise worries that bees can’t avoid neonicotinoid pesticides and that wild species are at special risk.  Read More Read More» Wild Things Before you plant this spring, consider the birds By Sarah Zielinski A study of Chicago neighborhoods finds that the plants in private yards influence the variety of birds that live in the area.  Read More Read More» More Headlines from Science News News in Brief Depression leaves lasting mark on DNA Stress affects cells at the molecular level. Read More By Tina Hesman Saey Science Ticker Atomic clock will keep precise time for 15 billion years The world’s most precise atomic clock will not lose or gain a second in roughly 15 billion years. Read More By Andrew Grant News Bolder snails grow stronger shells Bold snails have tougher shells than shy snails. Understanding what drives snails to develop such differences is a bit of a challenge. Read More By Ashley Yeager News Catching Zs may snag memories, too Flies genetically destined to be forgetful could boost their memory with sleep. Read More By Laura Sanders Context Old periodic table could resolve today’s element placement dispute A little-known genius figured out where all the elements in the periodic table should be placed long before some of them were discovered. Read More By Tom Siegfried Privacy Policy | Update Email Preferences | Unsubscribe from All SSP Newsletters | Contact Us Facebook | Twitter | YouTube | Google+ Society for Science & the Public • 1719 N Street, N.W. Washington, DC 20036 • Copyright © 2015

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Science News Weekly Alert

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New Science/AAAS Webinar Revealing the secrets of intractable cellular functions: All-in-one-well methods for studying protein interaction and secretion Wednesday, April 29, 2015, at 9 a.m. Pacific, 12 noon Eastern, 5 p.m. UK, 6 p.m. Central Europe Hear about new multiplexing tools that allow protein binding to be studied directly in cells, enabling high throughput analysis. Register TODAY: webinar.sciencemag.org Produced by the Science/AAAS Custom Publishing Office and sponsored by PerkinElmer. News from Science Weekly Headlines   24 April 2015 This week’s news from Science and ScienceInsider 24 April 2015 | Bad genes make mosquito bait 24 April 2015 | World’s dirtiest bird found in Vancouver 24 April 2015 | Watch: NASA reveals spectacular new Hubble images 24 April 2015 | SCIENTIFIC COMMUNITY Top stories: The vampire squid’s unusual sex life, 170-year-old champagne, and Yellowstone’s supervolcano A roundup of some of our favorite stories of the week 24 April 2015 | BIOLOGY Eagle versus porcupine: Camera snaps a painful face-off Study suggests such interactions may not be as rare as thought 24 April 2015 | BIOLOGY Breast cancer drug may help men with prostate cancer Drug halts tumor growth in a third of men with deadly form of disease 24 April 2015 | SCIENTIFIC COMMUNITY Podcast: Vampire squids, isolated tribes, and more Listen to a roundup of some of our favorite stories from the week 24 April 2015 | EARTH How to predict an avalanche with radar and GPS Scientists create an early warning system for snowslides 23 April 2015 | EARTH Two huge magma chambers spied beneath Yellowstone National Park Magma plumbing system that feeds volcano imaged completely for the first time 23 April 2015 | EARTH Thirty thousand square kilometers of land lost to oil and gas development First tally of drill site land area finds significant lost ecological productivity 23 April 2015 | Life in Tau Ceti system unlikely, scientists say 23 April 2015 | ARCHAEOLOGY Sophisticated tools may have spelled doom for Neandertals Ancient teeth reveal the identity of European toolmakers 23 April 2015 | SPACE Stripped and cast out, the universe's loneliest galaxies Study explains origin of rare elliptical galaxies 23 April 2015 | Invisibility can help calm nerves 23 April 2015 | BIOLOGY Technique aims to cut disease-causing mutations out of eggs and embryos Mouse study demonstrates method to target mutations in DNA inherited from mother 23 April 2015 | EARTH Cosmic rays could reveal secrets of lightning on Earth Scientists develop new technique to probe electric fields inside thunderstorms 23 April 2015 | EARTH Oil and gas operations could trigger large earthquakes Seventeen regions in eight states are at high risk for human-caused tremors, U.S. Geological Survey says 22 April 2015 | FUNDING U.S. House panel would slash Department of Energy's applied research White House hints at veto of budget bill for next year 22 April 2015 | PALEONTOLOGY Dino 'sexing' study slammed by critics Experts complain of methodological and ethical flaws 22 April 2015 | Scientists alter genomes of human embryos New Science/AAAS Webinar Revealing the secrets of intractable cellular functions: All-in-one-well methods for studying protein interaction and secretion Wednesday, April 29, 2015, at 9 a.m. Pacific, 12 noon Eastern, 5 p.m. UK, 6 p.m. Central Europe Hear about new multiplexing tools that allow protein binding to be studied directly in cells, enabling high throughput analysis. Register TODAY: webinar.sciencemag.org Produced by the Science/AAAS Custom Publishing Office and sponsored by PerkinElmer.

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