Table of Contents for 17 April 2015; Vol. 348, No. 6232

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Sponsored by BIOtech Japan 2015 – 14th Int’l Bio Technology Exhibition & Conference Science Table of Contents   04/17/15 Volume 348, Issue 6232 In this week’s issue: Research Summaries This Week in Science Editor summaries of this week’s papers. Editors’ Choice Highlights of the recent literature. Editorial One Arctic Fran Ulmer In Brief This week’s section A roundup of weekly science policy and related news. In Depth Conservation Meager snows spell trouble ahead for salmon Robert F. Service Without snowmelt, streams in the western U.S. could reach lethal temperatures. Faculty Hiring Women best men in study of tenure-track hiring Rachel Bernstein Female candidates twice as likely to get top rating. Arctic Policy U.S. lays out its ambitions for leadership in the Arctic Carolyn Gramling Climate, marine conservation, and renewable energy priorities as U.S. ascends to chair of Arctic Council. Planetary Science Moon-forming impact left scars in distant asteroids Eric Hand Planetary collision dated through analysis of meteorites. Sanitation For toilets, money matters Jocelyn Kaiser New work suggests that subsidies to the poor to buy latrines could help end open defecation. Particle Physics Japan accelerator poised to go fully operational Dennis Normile Closure after radiation leak ended up hampering some teams more than others. Feature Dawn of the dog David Grimm An unprecedented collaboration may solve one of the greatest mysteries of domestication. How the wolf became the dog David Grimm Scientists are coming to a consensus about how canines evolved. Working Life En pointe Elisabeth Pain Letters Shaping the future of synthetic biology Todd Kuiken Combating the next lethal epidemic Peter J. Hotez Outside the Tower More than a science camp Luciano Gastón Morosi Books et al. Animal Disease Control The fever on the farm Delia Grace Lessons from America’s early efforts to control livestock diseases. History of Science The evolution of evolution Jim Endersby Looking back at the theories that shaped modern evolutionary biology Books Received A listing of books received at Science during the week ending 10 April 2015. Policy Forum Conservation Improve customs systems to monitor global wildlife trade Hon-Ki Chan et al. Widely used trade codes lack taxonomic granularity ADVERTISEMENT Perspectives Evolution Dogs hijack the human bonding pathway Evan L. MacLean and Brian Hare Oxytocin facilitates social connections between humans and dogs [Also see Report by Nagasawa et al.] Infectious Disease Combating emerging viral threats Elena Bekerman and Shirit Einav Broad-spectrum antiviral drugs are under development to treat emerging viral diseases such as Ebola and dengue for which no specific, licensed treatments exist Developmental Biology A scar is born: Origins of fibrotic skin tissue Rachel Sennett and Michael Rendl A fibroblast lineage is characterized by an inherent ability to form scar tissue in skin [Also see Research Article by Rinkevich et al.] Neuroscience Systemically treating spinal cord injury Amanda P. Tran and Jerry Silver A drug that crosses the blood-brain barrier has therapeutic potential for central nervous system trauma [Also see Report by Ruschel et al.] Applied Optics Nanoplasmonic sensing and detection Mark I. Stockman Enhanced optical fields in nanoplasmonic systems provide efficient sensing and detection Structural Biology Mitoribosome oddities Roland Beckmann and Johannes M. Herrmann The mitochondrial ribosome has evolved structural differences from its cytosolic counterpart [Also see Report by Greber et al.] Oceanography Escape by dilution Jack J. Middelburg Dissolved organic matter in much of the deep ocean is too dilute to be consumed by microbes [Also see Report by Arrieta et al.] Reviews Evolutionary innovation and ecology in marine tetrapods from the Triassic to the Anthropocene Neil P. Kelley and Nicholas D. Pyenson The demands of a marine environment induced similar adaptations across multiple invasions of different vertebrate groups. Research Articles The complete structure of the 55S mammalian mitochondrial ribosome Basil J. Greber et al. The protein-synthesizing machinery of mammalian mitochondria differs substantially from bacterial and eukaryotic ribosomes. [Also see Perspective by Beckmann and Hermann] Identification and isolation of a dermal lineage with intrinsic fibrogenic potential Yuval Rinkevich et al. An embryonic fibroblast lineage deposits connective tissue in wounds. [Also see Perspective by Sennett and Rendl] Reports Subatomic resolution force microscopy reveals internal structure and adsorption sites of small iron clusters Matthias Emmrich et al. Torodial images of adsorbed metal atoms and clusters reflect their bonding symmetry. A strong magnetic field in the jet base of a supermassive black hole Ivan Martí-Vidal et al. A polarized signal offers evidence for the agent that boosts and guides powerful jets in a distant active galaxy. Evidence for mature bulges and an inside-out quenching phase 3 billion years after the Big Bang S. Tacchella et al. Mapping star-forming activity and densities shows an evolutionary connection between galaxies at z ~ 2.2 and those 10 million years later. Quasiparticle mass enhancement approaching optimal doping in a high-Tc superconductor B. J. Ramshaw et al. Quantum oscillation measurements track the doping dependence of the effective electron mass in the cuprate YBa2Cu3O6+δ. Dating the Moon-forming impact event with asteroidal meteorites W. F. Bottke et al. Impact heating caused by ejecta from a giant impact event confirms its timing through comparison of models and meteorites. The weakening summer circulation in the Northern Hemisphere mid-latitudes Dim Coumou et al. Warming in the Arctic has contributed to more extreme summer weather in the Northern Hemisphere. Volume loss from Antarctic ice shelves is accelerating Fernando S. Paolo et al. Ice shelves around much of Antarctica have been thinning over the past two decades. Dilution limits dissolved organic carbon utilization in the deep ocean Jesús M. Arrieta et al. Dilution is the reason why dissolved organic carbon in the deep ocean is not readily consumed by microbes. [Also see Perspective by Middleburg] Oxytocin-gaze positive loop and the coevolution of human-dog bonds Miho Nagasawa et al. The human-dog bond is facilitated by the interaction of oxytocin feedback loops that emerged over the course of domestication. [Also see Perspective by MacLean and Hare] Anthropogenic environmental changes affect ecosystem stability via biodiversity Yann Hautier et al. Experiments in grassland show that ecosystem stability is affected more by changes in biodiversity than in productivity. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness Pekka Katajisto et al. Stem cells preferentially select new rather than old mitochondria as they divide. Engineering of a superhelicase through conformational control Sinan Arslan et al. Locking a conformation into place with a cross-linker turns a DNA unzipping enzyme into a superhelicase. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury Jörg Ruschel et al. Stabilizing microtubules after a spinal cord injury reduces the migratory activity of scar-forming meningeal fibroblasts. [Also see Perspective by Tran and Silver] Direct observation of structure-function relationship in a nucleic acid–processing enzyme Matthew J. Comstock et al. Both structure and function can be studied at the same time while an enzyme unzips DNA. Technical Comments Comment on “Local reorganization of xanthophores fine-tunes and colors the striped pattern of zebrafish” Masakatsu Watanabe and Shigeru Kondo Response to Comment on “Local reorganization of xanthophores fine-tunes and colors the striped pattern of zebrafish” Ajeet Pratap Singh et al. Podcast Science Podcast: 17 April Show On this week’s show: The human-dog bond, a roundup of daily news stories. New Products New Products A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers. From the AAAS Office of Publishing and Member Services Business Office Feature Proteomics: Diving Deep into Cell Signaling Caitlin Smith     About the Cover Also Online: Science Express Daily News Science Careers Science Signaling Science Translational Medicine Recommend to Your Library Podcast Listen now. Latest News Feature: Solving the mystery of dog domestication How dogs stole our hearts Earth microbe prefers living on meteorites Japan says it will hunt whales despite science panel’s opposition Video: The secret to the octopus’s crawl ADVERTISEMENT Sponsored by BIOtech Japan 2015 – 14th Int’l Bio Technology Exhibition & Conference

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Science Express Notification for 17 April 2015

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Sponsored by Science & SciLifeLab Prize for Young Scientists    Want to be published in Science?    Want to receive US$30,000 for your research?    Now accepting entries    Science & SciLifeLab Prize for Young Scientists    Deadline: August 1, 2015    Visit www.sciencemag.org/scilifelabprize Science Science Express   04/17/15 Volume 348, Issue 6232 New Science Express articles have been made available: Research Articles The protein LEM promotes CD8+ T cell immunity through effects on mitochondrial respiration Isobel Okoye et al. Reports FERROELECTRICS Observation of a periodic array of flux-closure quadrants in strained ferroelectric PbTiO3 films Y. L. Tang et al. SANITATION SUBSIDIES Encouraging sanitation investment in the developing world: A cluster-randomized trial Raymond Guiteras et al. Near-atomic cryo-EM structure of the helical measles virus nucleocapsid Irina Gutsche et al. Sponsored by Science & SciLifeLab Prize for Young Scientists    Want to be published in Science?    Want to receive US$30,000 for your research?    Now accepting entries    Science & SciLifeLab Prize for Young Scientists    Deadline: August 1, 2015    Visit www.sciencemag.org/scilifelabprize

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Science Latest News

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Latest News and Headlines 15 April 2015

Love hormone turns mothers into moms

Video: A camera that powers itself

Subtly shifted star could force rethink of dark matter

Bone worms feasted on ancient sea monsters

Second Ebola vaccine trial may be too little, too late

World’s oldest stone tools discovered in Kenya

Lawmakers want to know: Do U.S. women face bias in winning federal research grants?

Withholding results from clinical trials is unethical, says WHO

Artificial trachea pioneer cleared in first of two misconduct cases

How sea snails learned to gobble fish

Women best men in STEM faculty hiring study

Blue lights could prevent bird strikes

Monkey deaths prompt probe of Harvard primate facility

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Sci Transl Med Table of Contents for 15 April 2015; Vol. 7, No. 283

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Sponsored by Association for Research in Vision and Ophthalmology Science Translational Medicine Table of Contents   04/15/15 Volume 7, Issue 283 Science Translational Medicine is pleased to sponsor the GTC European Pharma Summit (5-8 May, 2015 Berlin, Germany). Register today! Join Science Translational Medicine in Stockholm, Sweden, May 7-8, for Days of Molecular Medicine 2015 Last chance to register for Bridging Biomedical Worlds “From Neural Circuitry to Neurotechnology” in Tokyo. <!––> Science Translational Medicine welcomes our 2015 Associate Scientific Advisors. <!––> The focus of this week’s issue is cancer to coincide with the AACR annual meeting In this week’s issue: Research Articles CANCER PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor–positive breast cancer Ana Bosch et al. Inhibition of the PI3K/AKT pathway results in induction of ER-dependent transcriptional activity and susceptibility to anti-estrogen therapy in ER-positive breast cancer. CANCER STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade Juan Fu et al. Cyclic dinucleotide formulated cancer vaccine combined with PD-1 blockade can induce regression of tumors that do not express PD-L1 constitutively. CANCER Personalized genomic analyses for cancer mutation discovery and interpretation Siân Jones et al. Analysis of matched tumor and normal DNA from the same patient improves accuracy of identification of actionable mutations, allowing better targeting of potential treatments. CANCER Clonal status of actionable driver events and the timing of mutational processes in cancer evolution Nicholas McGranahan et al. Pan-cancer analysis of tumor subclonal structures uncovers widespread intratumor heterogeneity in actionable driver events and reveals mutational processes fueling their selection. CANCER Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients Michaela Semeraro et al. Natural killer cell activity and NKp30/B7-H6 interaction are prognostic biomarkers in high-risk neuroblastoma patients. Perspective CANCER Beyond 3D culture models of cancer Kandice Tanner and Michael M. Gottesman Three-dimensional culture models can represent cancer and its microenvironment and provide a platform for pharmaceutical testing. Review HEALTH CARE The emerging field of mobile health Steven R. Steinhubl et al. Mobile technologies can transform clinical research and health care worldwide—and save money. Editors’ Choice OBESITY Of obese mice and monkeys: Protective effects of PI3K inhibition Jessica A. Alvarez Inhibiting PI3K signaling in obese mice and rhesus monkeys safely reduced adiposity and metabolic abnormalities. COLORECTAL CANCER Beating BRAF resistance Sam Behjati A sequencing study defines resistance mechanisms to BRAF inhibition in colorectal tumors and reveals a possible Achilles’ heel. BIOMATERIALS Shaping up nicely Kara L. Spiller Sophisticated imaging reveals that the shape of implanted biomaterials determines their ability to support blood vessel growth. CANCER Singled out: Profiling metabolic and proteomic heterogeneity Ian Y. Wong A microfluidic assay enables multiplexed single-cell analysis of metabolites and proteins in glioblastoma cells.     About the cover Also Online: Current Issue Information for Authors My Science Translational Medicine Recommend to Your Library Sponsored by Association for Research in Vision and Ophthalmology

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The ethics of withholding clinical trial results, bias in winning research grants, & more

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Latest News and Headlines 14 April 2015

Second Ebola vaccine trial may be too little, too late

World’s oldest stone tools discovered in Kenya

Lawmakers want to know: Do U.S. women face bias in winning federal research grants?

Withholding results from clinical trials is unethical, says WHO

Artificial trachea pioneer cleared in first of two misconduct cases

How sea snails learned to gobble fish

Women best men in STEM faculty hiring study

Blue lights could prevent bird strikes

Monkey deaths prompt probe of Harvard primate facility

Saturns great white spots linked to water

Research advocates watch, warily, as Congress tries to finish its budget outline

Top stories: Humans are still evolving, Brontosaurus makes a comeback, and more

Smart phones could be used to detect earthquakes

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Science Signaling Table of Contents for 14 April 2015; Volume 8, Issue 372

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Sponsored by Cell Signaling Technology, Inc. Science Signaling Table of Contents   04/14/15 Volume 8, Issue 372 <!––> Science Signaling is pleased to sponsor the GTC European Pharma Summit in Berlin, Germany, 5-8 May 2015. Register today!<!– –> In this week’s issue: Focus Physiology Amino acid uptake in erythropoiesis David G. Nathan mTORC1 inhibitors may prevent hemoglobin production, thus potentially explaining why their use can be associated with anemias. Research Articles Physiology The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability Jacky Chung et al. Inadequate leucine uptake by maturing red blood cells limits the production of hemoglobin. DNA Damage Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization Lina Herhaus et al. The kinase CK2 promotes the nuclear function of the deubiquitylase OTUB1 in DNA damage repair. Microbiology Constitutive production of c-di-GMP is associated with mutations in a variant of Pseudomonas aeruginosa with altered membrane composition Andrea Blanka et al. Changes in the fatty acid composition of the plasma membrane in an opportunistic pathogen promote biofilm formation. Podcasts Microbiology Science Signaling Podcast: 14 April 2015 Susanne Häussler et al. Altered fatty acid metabolism enhances the ability of a disease-associated strain of Pseudomonas aeruginosa to form biofilms. Editors’ Choice Mechanotransduction Tailoring talin function Annalisa M. VanHook Different configurations of the integrin-talin-vinculin complex may enable talin to sense the different forces in developing tissues. Neuroscience Biased memories Sudhakaran Prabakaran Drugs targeting β-arrestin–biased signaling by β-adrenergic receptors may be helpful in memory-related disorders. Biochemistry Dual action: Demethylase and ubiquitin ligase Nancy R. Gough The unexpected E3 ubiquitin ligase activity of a histone demethylase suppresses cancer cell growth. Cancer Imatinib self-sabotages Leslie K. Ferrarelli The anticancer drug imatinib dampens its own toxicity by inducing a feedback loop that promotes proliferative signaling by fibroblast growth factor. Developmental Biology Slit halts muscles Annalisa M. VanHook Cleavage of Slit generates a membrane-associated N-terminal fragment that halts muscle migration in fly embryos. Cancer Immunology Vitamin D lends a helping hand Yevgeniya Nusinovich Vitamin D promotes tumoricidal activity of macrophages and improves the efficacy of antibody-dependent cellular cytotoxicity. Pharmacology Giving protein folding a helping hand Stella M. Hurtley Sephin1 selectively inhibits a protein phosphatase to prevent two protein misfolding diseases in mice. Biochemistry Single-molecule assay of ubiquitylation L. Bryan Ray The basis of an important enzyme-target recognition strategy is revealed at the single-molecule level. About the cover Also Online: Current Issue Table of Contents Science Signaling Homepage My Science Signaling Information for Authors Recommend to Your Library Sponsored by Cell Signaling Technology, Inc.

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Latest from Science News: Comet 67P shows no sign of magnetism

Latest from Science News 04/14/2015 View in browser Become a Subscribing Member» News in Brief Comet 67P shows no sign of magnetism BY Christopher Crockett, Apr 14, 2015 06:00 am Philae found no evidence of a magnetic field on comet 67P/Churyumov-Gerasimenko, but did send back some clues about its rough landing. Read More Read More» News in Brief Afterglow alerts astronomers to gamma-ray burst BY Andrew Grant, Apr 13, 2015 05:27 pm Astronomers have spotted the remnant glow from a gamma-ray burst without first observing its beam of high-energy gamma rays. Read More Read More» News in Brief Marijuana component fights epilepsy BY Nathan Seppa, Apr 13, 2015 04:41 pm A buzz-free extract of marijuana could help epilepsy patients whose seizures resist other treatments. Read More Read More» More Headlines from Science News Mystery Solved Source of puzzling cosmic signals found — in the kitchen One type of radio burst has a pretty mundane origin: prematurely opened microwave ovens. Read More By Christopher Crockett, Apr 10, 2015 04:19 pm Science Ticker Saying ‘I’ and ‘me’ all the time doesn’t make you a narcissist People who utter lots of first-person singular pronouns such as “I” and “me” score no higher on narcissism questionnaires than peers who engage in little “I”-talk. Read More By Bruce Bower, Apr 10, 2015 04:15 pm News Oil from BP spill probably sprayed out in tiny drops Oil that gushed from the well in the 2010 Deepwater Horizon spill may have shattered into tiny droplets, with high pressures doing the work of dispersants. Read More By Beth Mole, Apr 10, 2015 11:46 am Scicurious Serotonin and the science of sex Some scientists say that low serotonin makes male mice mate with males and females. Others disagree. In the end, it’s not about sexual preference, but about how science works. Read More By Bethany Brookshire, Apr 10, 2015 08:00 am Science Ticker Mountain gorilla genome reveals inbreeding Mountain gorillas are highly inbred, with good and bad consequences. Read More By Tina Hesman Saey, Apr 09, 2015 05:26 pm News in Brief Fossil reveals terror bird’s power Bones of a new terror bird confirm the creatures used their beaks to hatchet their prey but also raise questions about what drove the birds extinct. Read More By Ashley Yeager, Apr 09, 2015 04:00 pm Science Ticker Tyrannosaurs fought and ate each other Evidence from a tyrannosaur skull and jaw fossils add to the argument that the ancient reptiles fought and weren’t above scavenging their own. Read More By Helen Thompson, Apr 09, 2015 03:23 pm Privacy Policy | Update Email Preferences | Unsubscribe from All SSP Newsletters | Contact Us Facebook | Twitter | Vimeo | Google+ Society for Science & the Public • 1719 N Street, N.W. Washington, DC 20036 • Copyright © 2013

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Hi guys ,
        I know it has been a long time since we were active and we have found your dislike via the
un-likes and abandoned visits we had but it was just due to the annual exam of tenth std I had all of you might have for a student studies is the first priority and later comes all . now I am happy to inform you that all that is over now and we are going active forever .Anyway I thank all of you for you never ending support and hope that it would continue.
                                                                                                        Bharath krishnan
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