Science Express Notification for 15 May 2015

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New Science/AAAS and Science Signaling Webinar Part 3: Targeting Cancer Pathways: Tumor Metabolism and Proliferation Thursday, June 11, 2015, at 9 a.m. Pacific, 12 noon Eastern, 5 p.m. UK, 6 p.m. Central Europe Learn how tumor-specific metabolic changes promote oncogenic progression and how these changes can be exploited to develop more effective treatment options. Register TODAY: webinar.sciencemag.org Produced by the Science/AAAS Custom Publishing Office and sponsored by Cell Signaling Technology. Science Science Express   05/15/15 Volume 348, Issue 6236 New Science Express articles have been made available: Reports FRICTION Macroscale superlubricity enabled by graphene nanoscroll formation Diana Berman et al. SOCIAL EVOLUTION Genomic signatures of evolutionary transitions from solitary to group living Karen M. Kapheim et al. C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits Jeannie Chew et al. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer Robert J. A. Bell et al. New Science/AAAS and Science Signaling Webinar Part 3: Targeting Cancer Pathways: Tumor Metabolism and Proliferation Thursday, June 11, 2015, at 9 a.m. Pacific, 12 noon Eastern, 5 p.m. UK, 6 p.m. Central Europe Learn how tumor-specific metabolic changes promote oncogenic progression and how these changes can be exploited to develop more effective treatment options. Register TODAY: webinar.sciencemag.org Produced by the Science/AAAS Custom Publishing Office and sponsored by Cell Signaling Technology.

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The best time to freeze your eggs, dark matter in star clusters, & why galaxies die

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Latest News and Headlines 13 May 2015

Video: Spring-loaded jaws rocket ants to safety

Exposed to dangerous radiation? Telltale signs are in your blood

House spending panel calls for cuts at NASA, NOAA, and NIST, small increase for NSF

Why do galaxies die?

Australian budget winners: Big facilities and medical research

How long should a woman wait to freeze her eggs?

Star clusters may harbor dark matter

Updated: European Commission to appoint seven to new high-level science advice panel

Gut bacteria help turn animals into fossils

Rats forsake chocolate to save a drowning companion

How birds got their beaks

U.S. politicians say they want to help the working poor. But how many are there?

Australian university pulls plug on climate skeptic’s center

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Latest from Science News: Quicker sepsis diagnosis may be a step closer

Latest from Science News 05/14/2015 View in browser Become a Subscribing Member» Science Ticker Quicker sepsis diagnosis may be a step closer BY Ashley Yeager, May 14, 2015 06:00 am Identifying genes linked with sepsis may make it possible to develop a blood test to diagnose the infection days sooner than current methods. Read More Read More» Science Ticker New Horizons probe takes family photo of Pluto's moons BY Christopher Crockett, May 13, 2015 03:38 pm The New Horizons spacecraft finally spied Pluto’s two tiniest satellites, Kerberos and Styx, in a series of images taken from April 25, 2015 to May 1, 2015. Read More Read More» News MicroRNAs track radiation doses BY Tina Hesman Saey, May 13, 2015 02:00 pm MicroRNAs in the blood may indicate radiation damage, a study of mice finds. Read More Read More» More Headlines from Science News News Nighttime light pollution sabotages sex pheromones of moths Artificial lighting at night can trick female moths into releasing skimpy, odd-smelling sex pheromones. Read More By Susan Milius, May 13, 2015 07:00 am Science Ticker Pruning bug genitals revives puzzle of extra-long males Surgical approach highlights question of length mismatch in his and hers morphologies. Read More By Susan Milius, May 12, 2015 07:29 pm Science Ticker Too much light slows brown fat, suggesting link with obesity Brown fat is supposed to be the friendly kind, but making the days longer with artificial light may turn it into an enemy in the battle against obesity. Read More By Ashley Yeager, May 12, 2015 03:30 pm Wild Things An island in the Maldives is made of parrotfish poop Coral-eating parrotfish create much of the sediment that a reef island is made of, a new study finds. Read More By Sarah Zielinski, May 12, 2015 02:30 pm Science Ticker Another strong quake strikes Nepal A magnitude 7.3 earthquake hit eastern Nepal on May 12, just 17 days after one that killed more than 8,000 people in the region. Read More By Thomas Sumner, May 12, 2015 01:13 pm Science Ticker Ancient brain fossils hint at body evolution of creepy-crawlies Fossilized brains — found in the Burgess Shale in western Canada — offer clues to how arthropods morphed from soft- to hard-bodied animals. Read More By Teresa Shipley Feldhausen, May 12, 2015 11:40 am News Molecular scissors snip at cancer’s Achilles’ heel Finding cancer’s vulnerable spots using CRISPR technology could lead to drugs that hit the disease hard. Read More By Meghan Rosen, May 12, 2015 10:59 am Privacy Policy | Update Email Preferences | Unsubscribe from All SSP Newsletters | Contact Us Facebook | Twitter | Vimeo | Google+ Society for Science & the Public • 1719 N Street, N.W. Washington, DC 20036 • Copyright © 2015

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Sci Transl Med Table of Contents for 13 May 2015; Vol. 7, No. 287

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Sponsored by Pall Corporation Science Translational Medicine Table of Contents   05/13/15 Volume 7, Issue 287 Did you miss…? Contemplating the role of CTSAs in precision medicine <!– Join Science Translational Medicine in Stockholm, Sweden, May 7-8, for Days of Molecular Medicine 2015 Last chance to register for Bridging Biomedical Worlds “From Neural Circuitry to Neurotechnology” in Tokyo. –> <!– Science Translational Medicine welcomes our 2015 Associate Scientific Advisors. –> <!– The focus of this week’s issue is cancer to coincide with the AACR annual meeting –> In this week’s issue: Research Articles RADIATION INJURY Serum microRNAs are early indicators of survival after radiation-induced hematopoietic injury Sanket S. Acharya et al. Serum miRNAs can predict long-term radiation-induced hematopoietic injury immediately after radiation and thereby facilitate timely medical intervention and improve overall survival of exposed individuals. IMMUNOTHERAPY Anti-CD20/CD3 T cell–dependent bispecific antibody for the treatment of B cell malignancies Liping L. Sun et al. Anti-CD20/CD3 T cell–dependent bispecific antibodies may be useful for the treatment of B cell malignancies. SEPSIS A comprehensive time-course–based multicohort analysis of sepsis and sterile inflammation reveals a robust diagnostic gene set Timothy E. Sweeney et al. Five publicly available gene expression cohorts comparing SIRS/trauma to sepsis were split into time-matched subcohorts and summarized via multicohort analysis, which yielded an 11-gene set that was validated for discriminating patients with sepsis or infection in 15 independent cohorts. PAIN The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors Jeffrey S. Wieskopf et al. Finding that nicotinic receptors containing the α6 subunit, but not the α4, inhibit chronic pain points to a new set of potential therapeutic drugs. INFECTIOUS DISEASE Classic reaction kinetics can explain complex patterns of antibiotic action Pia Abel zur Wiesch et al. Chemical reaction kinetics explain three different effects of drug-mediated bacterial killing. MULTIPLE SCLEROSIS Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis Yonghao Cao et al. CCR6+ myelin-reactive T cells from patients with multiple sclerosis secrete inflammatory cytokines compared to T cells from healthy subjects, showing a distinct pathogenic gene expression profile and sharing a transcriptome homology with encephalitogenic CD4+ T cells isolated from mice with experimental autoimmune encephalitis. Focus EDUCATION How to know when physicians are ready for genomic medicine Jason L. Vassy et al. Despite perceptions to the contrary, physicians are as prepared for genomic medicine as they are for other medical innovations. CHAMPIONS OF TRANSLATION William Heberden and reverse translation Elazer R. Edelman and Kelly LaMarco Eighteenth-century physician-scientist William Heberden transformed science, medicine, and society in ways that remain relevant today. Editors’ Choice RETINAL PROSTHETICS Stimulated sight Pamela Bhatti Electrical stimulation of retinal neurons using photovoltaics restores sight in rats with retinal degradation. MALARIA Malaria gives mosquitoes the munchies Nicole M. Bouvier The malaria parasite Plasmodium falciparum synthesizes the same chemical signals that attract the mosquito vector to nectar-producing plants. CANCER It takes two to tango Biju Parekkadan An engineered IL-2 fusion protein collaborates with T cell therapy to induce a multifaceted immune response in mouse tumor models. GLUCOSE TOLERANCE Night and day: Circadian rhythms and glucose tolerance Jeffrey Statland Sleep/wake cycles and timing of meals affect glucose tolerance, emphasizing the intricate homeostatic mechanisms behind glucose control. CANCER More precision in lung cancer therapy Anish Thomas New drugs specifically targeting EGFR-sensitizing mutations and the EGFR T790M resistance mutation are associated with clinical benefit in lung cancer patients with acquired EGFR T790M mutations. Errata Erratum for the Research Article: “Prostate cancer cell–stromal cell crosstalk via FGFR1 mediates antitumor activity of dovitinib in bone metastases” by X. Wan, P. G. Corn, J. Yang, N. Palanisamy, M. W. Starbuck, E. Efstathiou, E. M. Tapia, A. J. Zurita, A. Aparicio, M. K. Ravoori, E. S. Vazquez, D. R. Robinson, Y.-M. Wu, X. Cao, M. K. Iyer, W. McKeehan, V. Kundra, F. Wang, P. Troncoso, A. M. Chinnaiyan, C. J. Logothetis, N. M. Navone Erratum for the Research Article: “Mitigation of tracheobronchomalacia with 3D-printed personalized medical devices in pediatric patients” by R. J. Morrison, S. J. Hollister, M. F. Niedner, M. G. Mahani, A. H. Park, D. K. Mehta, R. G. Ohye, G. E. Green     About the cover Also Online: Current Issue Information for Authors My Science Translational Medicine Recommend to Your Library Sponsored by Pall Corporation

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How birds got their beaks, turning off the lights to burn fat, & more

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Latest News and Headlines 12 May 2015

Rats forsake chocolate to save a drowning companion

How birds got their beaks

U.S. politicians say they want to help the working poor. But how many are there?

Australian university pulls plug on climate skeptic’s center

Could turning out the lights help you burn fat?

Many twin stars may actually be triplets

A few kind words could help politicians win elections

Antarctic researchers ponder challenges posed by increasing sea ice

Pricey new hepatitis C and cancer drugs make Essential Medicines List

Discovered a disease? WHO has new rules for avoiding offensive names

Sea level rise accelerating faster than thought

Drug-resistant typhoid fever becoming an epidemic in Africa and Asia

Top stories: Imaging atoms, digging for diamonds, and oxygen in space

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Science Signaling Table of Contents for 12 May 2015; Volume 8, Issue 376

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Sponsored by Cell Signaling Technology, Inc. Science Signaling Table of Contents   05/12/15 Volume 8, Issue 376 <!––> Don’t miss the Focus Issue on reproducibility!<!– –> In this week’s issue: Research Articles Vascular Biology Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition Yi Xie et al. Increasing the activity of the transcription factor GATA-6 prevents excessive proliferation of vascular smooth muscle cells in injured blood vessels. Neurodegeneration Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders Stefano G. Daniele et al. Patients with neurodegenerative disorders called synucleinopathies may benefit from drugs that inhibit inflammatory receptors on microglia in the brain. EGFR Signaling EGFR-activated Src family kinases maintain GAB1-SHP2 complexes distal from EGFR Christopher M. Furcht et al. Activation of Src family kinases enables ligand-initiated signaling to persist in the cytoplasm after the receptor is turned off. Podcasts Neurodegeneration Science Signaling Podcast: 12 May 2015 Kathleen A. Maguire-Zeiss et al. Drugs that inhibit signaling by pattern recognition receptors on microglia reduce neuroinflammation associated with synucleinopathies such as Parkinson’s disease. Editors’ Choice Developmental Neuroscience Epigenetically programming gender identity Leslie K. Ferrarelli Gender identity in the brain is regulated by DNA methylation during a short time around birth. Neuroscience Excited by GABA Annalisa M. VanHook In a model of Down syndrome, signaling through GABAA receptors is excitatory rather than inhibitory. Developmental Neuroscience Perineuronal nets close the door on brain development Katrina L. Kelner Excessive HRAS signaling in Costello syndrome accelerates Ras-specific astroglial development and extracellular matrix accumulation, resulting in premature cortical circuit maturation. Cell Biology Discrete PTEN signaling Sudhakaran Prabakaran The phosphatase PTEN must be localized to cytoplasmic vesicles to oppose PI3K signaling. Cellular Metabolism How inhibition of TORC1 stimulates gene expression Annalisa M. VanHook The transcription factors REPTOR and REPTOR-BP stimulate the expression of nutrient stress genes in response to reduced TORC1 signaling. Immunology Keeping T cells in place Wei Wong Adiponectin stimulates B cells to release a peptide that restricts the transendothelial migration of T cells. Host-Pathogen Interactions A way to dissect malaria’s secrets Stella M. Hurtley A screening approach reveals host factors critical for human malaria parasite invasion of red blood cells. About the cover Also Online: Current Issue Table of Contents Science Signaling Homepage My Science Signaling Information for Authors Recommend to Your Library Sponsored by Cell Signaling Technology, Inc.

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Latest from Science News: Japanese satellite stalls in space and won’t reach its asteroids

Latest from Science News 05/12/2015 View in browser Become a Subscribing Member» Science Ticker Japanese satellite stalls in space and won't reach its asteroids BY Christopher Crockett, May 12, 2015 06:00 am Because of an engine failure, the Japanese Space Agency’s PROCYON spacecraft won’t make it to its target binary asteroid. Read More Read More» News in Brief Tameness is in the genes BY Tina Hesman Saey, May 11, 2015 04:04 pm Taming affects common genes in multiple species. Read More Read More» Science Ticker Bright spots on Ceres may be made of smaller patches of ice BY Christopher Crockett, May 11, 2015 03:45 pm The Dawn spacecraft took a closer look at bright patches and craters on the dwarf planet Ceres. Read More Read More» More Headlines from Science News Growth Curve Children’s cells live on in mothers A baby’s cells knit their way into a mother’s body. Read More By Laura Sanders, May 10, 2015 06:00 am Wild Things Animal moms sacrifice a lot — sometimes even themselves In the animal kingdom, there are bad mothers and good ones — and then there are those that let their kids eat them. Read More By Sarah Zielinski, May 08, 2015 02:00 pm News in Brief Fingerprints give away more than identity Scientists can now detect and measure the amount of illegal drugs, such as cocaine and heroin, on a lone fingerprint. Read More By Beth Mole, May 08, 2015 01:45 pm Scicurious A vivid emotional experience requires the right genetics A single gene deletion gives some people an extra vivid jolt to their emotional experience, a new study shows. Read More By Bethany Brookshire, May 08, 2015 11:43 am News in Brief Flood planners should not forget beavers Beaver dams can reduce flooding downstream, new research shows. Read More By Thomas Sumner, May 08, 2015 08:00 am Science Ticker Pig farm workers at greater risk for drug-resistant staph Pig farm workers are six times as likely to carry multidrug-resistant staph than workers who have no contact with pigs. Read More By Beth Mole, May 08, 2015 07:00 am Science Ticker Resistors that remember help circuits learn Electronic components called memristors have enabled a simple computing circuit to learn to perform a task from experience. Read More By Andrew Grant, May 07, 2015 04:30 pm Privacy Policy | Update Email Preferences | Unsubscribe from All SSP Newsletters | Contact Us Facebook | Twitter | Vimeo | Google+ Society for Science & the Public • 1719 N Street, N.W. Washington, DC 20036 • Copyright © 2015

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Accelerating sea level rise, drug-resistant typhoid fever, & more

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Latest News and Headlines 11 May 2015

Could turning out the lights help you burn fat?

Many twin stars may actually be triplets

A few kind words could help politicians win elections

Antarctic researchers ponder challenges posed by increasing sea ice

Pricey new hepatitis C and cancer drugs make Essential Medicines List

Discovered a disease? WHO has new rules for avoiding offensive names

Sea level rise accelerating faster than thought

Drug-resistant typhoid fever becoming an epidemic in Africa and Asia

Top stories: Imaging atoms, digging for diamonds, and oxygen in space

Bats open wide to focus their ultrasonic beams

Traffic noise blocks fish sex

Liberia’s Ebola epidemic ends

Nobel laureates defend E.U. animal research rules against citizens proposal

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“Advances in addiction research” – SIGN UP NOW for our newest Science Webinar!

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New complimentary webinar from Science: Advances in addiction research: Applying genetic biomarkers to personalize treatments You are invited to hear our panel of experts on June 3, 2015, in this live, online educational seminar. For more information and complimentary registration visit: webinar.sciencemag.org Date: Wednesday, June 3, 2015 Time: 12 noon Eastern, 9 a.m. Pacific, 5 p.m. UK, 6 p.m. Central Europe Duration: 1 hour About This Webinar Advancements in genetics, sequencing technology, and bioinformatics are changing the principles of current medical practice and transforming the standards of patient care. Genetic detection of common and rare variants within populations provides valuable information about predisposition and vulnerability to complex human disease. Data from large-scale genome-wide association studies have identified genetic variations correlated to biological events, enabling combinations of genetic and non-genetic markers to be translated into potential diagnostic tools. However, aspects of these programs are still evolving, including best practices for protocol development, sample processing, genetic/genomic analysis, data management, and quality control. In this webinar, our expert panel will discuss how to better define these procedures and maximize the use of precious, limited clinical samples by utilizing recent innovations, advances in technology, and current best practices. During the webinar, the speakers will: • Discuss the development and application of a targeted genotyping array for genetic research on addiction and treatment approaches • Present the advantages of fully automated genotyping platforms, the importance of functional quality control for biomaterials, and provide guidance on sample management best practices for discovery and translational research • Explain how advancements in technologies, including novel bioinformatics and analytic tools are supporting the development of new biomarkers • Answer your questions live during the broadcast! <!– • Have their questions answered live by the panelists! –> Participants: Andrew Brooks, Ph.D. Rutgers University New Brunswick, NJ James Baurley, Ph.D. BioRealm, LLC Monument, CO <!– Giridharan Periyasamy, Ph.D. Genome Institute of Singapore Singapore, Malaysia –> Register at: webinar.sciencemag.org Questions? E-mail: webinar@aaas.org. Produced by the Science/AAAS Custom Publishing Office and sponsored by:

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Traffic noise blocks fish sex, bat beams, & more

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Latest News and Headlines 8 May 2015

Bats open wide to focus their ultrasonic beams

Traffic noise blocks fish sex

Liberia’s Ebola epidemic is almost over

Nobel laureates defend E.U. animal research rules against citizens proposal

Earthquake sensors could help predict rockfalls

Mini-guts grown from colon cancers spark new treatment hopes

X-rays reveal how chocolate turns white

Electron microscopes close to imaging individual atoms

Measles vaccine protects against other deadly diseases

Is Facebook keeping you in a political bubble?

Ancient Mercury had a magnetic field

Podcast: A plant that finds diamonds, the evolution of pop music, and why Americans smile more than Russians and Chinese

U.S. Senate makes progress on chemical regulation reform, but obstacles await

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