Sci Transl Med Table of Contents for 06 May 2015; Vol. 7, No. 286

Sponsored by Harrington Discovery Institute at University Hospitals in Cleveland

The Harrington Prize for Innovation in Medicine Nominations due August 28, 2015.
The Harrington Prize for Innovation in Medicine, presented by the American Society for Clinical Investigation and the Harrington Discovery Institute, honors the physician-scientist who has moved science forward with notable achievements in innovation, creativity and potential for clinical application. Submit a nomination at www.HarringtonDiscovery.org.

Science/AAAS Science Translational Medicine

Table of Contents
 

05/06/15 Volume 7, Issue 286


GTC

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Science Translational Medicine welcomes our 2015 Associate Scientific Advisors.

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The focus of this week’s issue is cancer to coincide with the AACR annual meeting

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In this week’s issue:


Research Articles

NEURODEVELOPMENTAL DISORDERS

Excessive HRAS signaling in Costello syndrome accelerates Ras-specific astroglial development and extracellular matrix accumulation, resulting in premature cortical circuit maturation.

BILIARY ATRESIA

A plant toxin with a previously uncharacterized chemical structure causes biliary atresia in zebrafish and mammals.

WOUND HEALING

Enterococcus faecalis depletes intestinal collagen, activates the host tissue protease MMP9, and contributes to anastomotic leak.


Reports

BIOENGINEERING

Loa loa microfilariae load in blood can be automatically quantified at the point of care using a mobile phone video microscope.

MALARIA

Vaccination with the recombinant viral vectors chimpanzee adenovirus 63 followed by modified vaccinia Ankara both encoding the malaria sequence ME-TRAP conferred 67% protection against infection with Plasmodium falciparum in Kenyan adults.


Perspective

VACCINES

Immunological data could be used to demonstrate Ebola vaccine efficacy.

POLICY

The best way to mitigate disruption of the pharmaceutical industry is to sponsor initiatives that keep scientists engaged.


Editors’ Choice

IMMUNOLOGY

AAV capsid preference toward cell-surface receptors determines not just its tissue specificity but also plays a key role in immune activation.

IMMUNOLOGY

A liver-specific mechanism of effector CD8+ T cell immune surveillance is inhibited by liver fibrosis.

POLICY

A compilation of case studies suggests that the decline in investment in U.S. basic science research threatens innovation and thus the U.S. economy.

 
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The Harrington Prize for Innovation in Medicine Nominations due August 28, 2015.
The Harrington Prize for Innovation in Medicine, presented by the American Society for Clinical Investigation and the Harrington Discovery Institute, honors the physician-scientist who has moved science forward with notable achievements in innovation, creativity and potential for clinical application. Submit a nomination at www.HarringtonDiscovery.org.

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Feathered fossils, finding listeria, & more

 

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Why there is so little breathable oxygen in space
 

 
 

 

 

Feathered fossils from China reveal dawn of modern birds
 

 
 

 

 

Sequencing finds listeria in unlikely places
 

 
 

 

 

What your smile says about where you’re from
 

 
 

 

 

Gene therapy for blindness may fade with time
 

 
 

 

 

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Whales have elastic nerves
 

 
 

 

 

Vote for your favorite #upwardfacingdog!
 

 
 

 

 

Rare African plant signals diamonds beneath the soil
 

 
 

 

 

Meet the finalists of our #upwardfacingdog contest
 

 
 

 

 

House panel holds hearing on politically driven science—sans scientists
 

 
 

 

 

Silver turns bacteria into deadly zombies
 

 
 

 

 

Analysis: In boosting climate goals, California daring others to follow
 

 
 

 

 


Dog
 

 
 

 

   

 

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Science Signaling Table of Contents for 05 May 2015; Volume 8, Issue 375

Sponsored by the Science/AAAS Custom Publishing Office

Watch Previously Recorded Webinars from Science/AAAS
View our collection of over 50 webinars on webinar.sciencemag.org and learn how today’s research is shaping tomorrow’s discoveries. Featuring presentations from world renowned experts on a broad range of topics, including Noncoding RNAs, Imaging, Apoptosis, qPCR, Next-Gen Sequencing, and Stem Cell Research, the webinars are a tremendous learning tool that include previously recorded question and answer segments.

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Science/AAAS Science Signaling

Table of Contents
 

05/05/15 Volume 8, Issue 375


gtc Attend GTCbio’s European Pharma Summit to network with the best in drug discovery [5-8 May 2015, Berlin, Germany]: Register today!<!–
–>

In this week’s issue:


Research Articles

Regeneration

Inhibiting the Hippo pathway could promote heart regeneration by encouraging heart cells to move into injured areas.

Cancer

Oncogenic feedback loops explain how loss of a microRNA enhances proliferative signaling in glioblastoma.

Plant Biology

The phosphatase ABI2 enables plants to efficiently uptake and respond to changes in nitrogen availability.


Podcasts

Regeneration

The transcriptional coactivator Yap promotes migration of cardiomyocytes to the site of injury during heart regeneration.


Editors’ Choice

Developmental Neuroscience

Myelination defects associated with premature birth may be ameliorated by drugs that activate GABA receptors.

Cancer

NDRG3 binds to lactate produced in hypoxic cells and stimulates proliferation and angiogenesis.

Immunology

The intracellular sensor NLRP12 inhibits inflammatory T cell responses and T cell–dependent diseases.

Parasitology

A mutation that thwarts the ability of an antimalarial drug to inhibit production of a signaling lipid confers drug resistance to the parasite Plasmodium falciparum.

DNA Repair

Surveying the battery of proteins required to repair covalently linked DNA strands reveals a new repair pathway.

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Watch Science Webinars today at webinar.sciencemag.org.


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Whales have elastic nerves, fading results for blindness therapy, & more

 

Latest News and Headlines

4 May 2015

 

 

 

Gene therapy for blindness may fade with time
 

 
 

 

 

Embattled Max Planck neuroscientist quits primate research
 

 
 

 

 

Whales have elastic nerves
 

 
 

 

 

Vote for your favorite #upwardfacingdog!
 

 
 

 

 

Rare African plant signals diamonds beneath the soil
 

 
 

 

 

Meet the finalists of our #upwardfacingdog contest
 

 
 

 

 

House panel holds hearing on politically driven science—sans scientists
 

 
 

 

 

Silver turns bacteria into deadly zombies
 

 
 

 

 

Analysis: In boosting climate goals, California daring others to follow
 

 
 

 

 

U.S. House bill would slash NASA earth science
 

 
 

 

 

PLOS ONE ousts reviewer, editor after sexist peer-review storm
 

 
 

 

 

Tiny plastic particles propel themselves like bacteria
 

 
 

 

 

Space radiation may damage astronauts’ brains
 

 
 

 

 


Dog
 

 
 

 

   

 

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Latest from Science News: Stretchy nerves help some big whales open wide

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05/05/2015

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Stretchy nerves help some big whales open wide

BY Ashley Yeager,

Blue whales and their closest relatives have stretchy nerves near their mouths so they can open wide and swallow a lot of prey. Read More

Science Visualized

‘Brainbow’ illuminates cellular connections

BY Ashley Yeager,

A mouse’s optic nerve fluoresces in a rainbow of colors. The image offers a detailed look at nerve-protector cells called oligodendrocytes. Read More

News

Sugar-cleaving molecule raises hope for universal blood

BY Beth Mole,

An engineered enzyme can quickly slice and dice some A and B markers from blood cells, bringing researchers closer to creating universal blood. Read More

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Space radiation, zombie bacteria, & more

 

Latest News and Headlines

1 May 2015

 

 

 

House panel holds hearing on politically driven science—sans scientists
 

 
 

 

 

Silver turns bacteria into deadly zombies
 

 
 

 

 

Analysis: In boosting climate goals, California daring others to follow
 

 
 

 

 

U.S. House bill would slash NASA earth science
 

 
 

 

 

PLOS ONE ousts reviewer, editor after sexist peer-review storm
 

 
 

 

 

Tiny plastic particles propel themselves like bacteria
 

 
 

 

 

Space radiation may damage astronauts’ brains
 

 
 

 

 

Top stories: A poisonous poop cocktail, sexist peer review, and 3D printed implants
 

 
 

 

 

Podcast: Cosmic rays, a feces cocktail, and a porcupine-eagle face-off
 

 
 

 

 

Scientists call for limits on emerging class of common, long-lived chemicals
 

 
 

 

 

In symbolic blow, Native Hawaiian panel withdraws support for worlds largest telescope
 

 
 

 

 

In the wake of new cures bill, NIH celebrates while FDA mulls responsibilities
 

 
 

 

 

APA hit with new torture allegations
 

 
 

 

 

 

 
 

 

   

 

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Editor’s picks: Travel diary for Curiosity, more quake potential in Himalayas, Newton’s gravitational constant, gliding dinos, & babies on the brain 

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05/03/15

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The Martian Diaries

By Alexandra Witze

Curiosity has explored Mars for over two and a half years. What if NASA’s rover kept a scrapbook? Read More

News

Stronger quakes could strike other segments of Nepal fault

By Thomas Sumner

The magnitude 7.8 earthquake that struck Nepal’s capital city could be overshadowed by larger future earthquakes along the Himalayas, scientists say. Read More

News

Explanation for G’s imprecision stumbles

By Andrew Grant

A surprising new result seems to suggest that subtle changes in Earth’s rotation rate could account for physicists’ difficulty in measuring Newton’s gravitational constant. But some confusion with dates appears to derail the finding. Read More

The Science Life

Brain on display

By Laura Sanders

In her online videos, Nancy Kanwisher goes where few other neuroscientists go. Read More

News

Tiny explosions add up to heat corona

By Christopher Crockett

Millions of mini-explosions every second on the sun could solve the riddle of why the sun’s atmosphere is so much warmer than its surface. Read More

News

This dinosaur’s ride may have been a glide

By Ashley Yeager

A new dino called Yi qi may have taken to the skies with wings akin to those of pterosaurs and flying squirrels. Read More

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Explainer: What are lidar, radar and sonar?

By Andrew Bridges,

Radar, sonar and lidar and are three similar technologies. Each relies on the echoing of waves — radio, sound or light waves — to detect objects. Read More

Ancient Times, Technology & Engineering

Laser vision reveals hidden worlds

By Stephen Ornes,

From discovering ancient ruins to forecasting climate change, the laser mapping technology called lidar is changing many fields of science. Read More

Brain & Behavior, Weather & Climate

Twisters: Can warning people too early backfire?

By Thomas Sumner,

If people think they have enough time to flee a tornado, they may try to drive away, information shows. This could leave them stuck in traffic — with no protection — when the storm does show up. Read More

Earth

Nepal earthquake offers hints of worse to come

By Thomas Sumner,

The magnitude 7.8 earthquake that crumbled much of Nepal’s capital city could be overshadowed by larger future earthquakes along the Himalayas, scientists say. Read More

Dinosaurs & Fossils

'Frankenstein' dino showed a mashup of traits

By Ashley Yeager,

New species unearthed in Chile is “an anatomical Frankenstein,” declares one of its discoverers. Read More

Chemistry

How sweat might make you smell sweeter

By Sharon Oosthoek,

A new scent-delivery system ensures that the more you sweat, the more perfume it releases. In fact, it only works in contact with moisture. Read More

Environment & Pollution, Plants

News Brief: Smokin’ plants

By Janet Raloff,

A new study points out how some herb teas and spices could have accidentally picked up nicotine from the smokers working around them. Read More

Body & Health

News Brief: Ebola’s dead stay infectious for a week

By Janet Raloff,

The Ebola virus doesn’t die with its victims — at least not right away. A corpse may host live virus for up to a week after death, a new study finds. Read More

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Science News Weekly Alert


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Weekly Headlines
 

1 May 2015

This week’s news from Science and ScienceInsider

01 May 2015 | POLICY
Discussion delves into role of government research
01 May 2015 | BIOLOGY
Dead bacteria “sponges” soak up the metal and kill their relatives
01 May 2015 | CLIMATE
Ambitious new targets aim to improve economy, environment
01 May 2015 | EARTH
Added funding for planetary missions does not mollify critics
01 May 2015 | SCIENTIFIC COMMUNITY
Reviewer’s remarks prompted Twitter outrage
01 May 2015 |
01 May 2015 | CHEMISTRY
Work could have applications for energy production and drug delivery
01 May 2015 | BRAIN BEHAVIOR
Mouse study suggests cosmic rays impair memory, cognition
01 May 2015 | SCIENTIFIC COMMUNITY
This week’s top science news
01 May 2015 |
01 May 2015 | SCIENTIFIC COMMUNITY
Listen to a roundup of some of our favorite stories from the week
01 May 2015 | CHEMISTRY
Madrid Statement urges action on fluorinated compounds
01 May 2015 | POLICY
But Office of Hawaiian Affairs declines to oppose project
30 April 2015 | FUNDING
U.S. lawmakers get first feedback on proposal
30 April 2015 | SCIENTIFIC COMMUNITY
E-mails hint at deeper APA involvement in harsh interrogations
30 April 2015 | BIOLOGY
Study finds genetic and hormonal origins of chondrichthyan sex organs
30 April 2015 | PEOPLE EVENTS
Researchers analyze social media to spot “the tipping point” in the Baltimore riots
30 April 2015 | SCIENTIFIC COMMUNITY
Think you have the science smarts to win on Jeopardy!?
30 April 2015 | BIOLOGY
Analysis of more than 100 studies finds rising extinctions with higher global temperature
30 April 2015 | BIOLOGY
Study finds clues to senescence in cells given rare aging disorder


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Weekly News

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Science/AAAS Science

Weekly News
 

05/01/15 Volume 348, Issue 6234

A roundup of the week’s top stories in Science:


In Brief

In science news around the world, the U.S. Geological Survey’s new earthquake hazards map finds new danger zones in the central United States due to oil- and gas-related wastewater injection; invasive lionfish in the Caribbean have spread to Brazil’s coral reefs; a replica of the 36,000-year-old Chauvet ave paintings opens to viewers in a nearby village in France; U.S. political parties continue to wrangle over a controversial bill to reshape U.S. science policy; and more. Also, NASA’s MESSENGER spacecraft has reached the end of its mission and is poised to crash into the planet. And the final results from a clinical trial of the first malaria vaccine are in—and they are as lackluster as preliminary results suggested they would be.


In Depth

Seismology

Geophysicists studying the rupture mechanics of the magnitude-7.8 earthquake in Nepal have made a startling discovery: that the quake extended deep into the Himalayas, into a region that many scientists had deemed incapable of explosive tearing. The rupture extended past a “lock line” where brittle rock becomes more plastic in its behavior—a region where slip was expected to creep along quietly and not contribute to the overall power of the earthquake. The discovery suggests that, as awful as the present disaster is, future earthquakes in the Himalayas could end up being mightier and more calamitous than modelers assumed.

Infectious Diseases

Ebola is on the decline in Guinea, one of three West African hit hard by the epidemic. The country’s teeming capital of 2 million, Conakry, had only a single known case last week. As part of the endgame, hundreds of local workers have gone house to house in the remaining Ebola pockets in recent weeks to explain how Ebola spreads, encourage people to report suspected cases, and try to find any hidden Ebola patients or corpses. Distrust of the government, resentment against teams raising awareness, and rumors about the origins of the epidemic are still a problem.

Bioethics

On 18 April, a Chinese team published the first-ever report on genetically altered human embryos. It ignited a firestorm of controversy and exposed a rift in the scientific community. Researchers at Sun Yat-sen University in Guangzhou reported how they attempted to use the CRISPR-Cas9 system, a new gene-editing technology, to modify the gene that causes the blood disorder beta thalassemia in abnormal human embryos rejected for in vitro fertilization use. They had minimal success altering the gene and said the technique is not yet ready for clinical use. Although approved by an ethics review board, the research set off alarms. Scientists agree there should be a moratorium on clinical use of genome editing at present. But some also want a moratorium on fundamental experiments; others are equally adamant that basic research using human embryos is scientifically and ethically justifiable.

Nutrition

Monitoring—and modifying—diet isn’t easy, as people struggling with obesity or diabetes are well aware. Keeping track of the added sugars that lurk in foods from soft drinks to cereals is especially hard. Researchers have now come up with a blood test that could help both average people trying to stay on top of their diets and nutritionists—and they’ve shown that it is as good at monitoring added sugars as the complex diet reporting usually used in medicine and research. The test, based on the ratio of common carbon isotopes in blood serum, has shown that just one sugar-sweetened beverage is enough to produce a detectable increase in carbon-13 in the blood. Researchers hope the test will eventually be a part of standard clinical blood panels.

Funding

Greece’s ongoing economic crisis and political shifts are taking a new toll on the country’s researchers, already reeling from cuts in salaries and research spending. Now, the government plans to confiscate research funding to plug a hole in the country’s ever worsening finances. As Science went to press, it remained unclear exactly how much money would be targeted and when it would be taken, but researchers expect the government to grab funds set aside to pay for research overheads. And the left-wing government, in power since January, is pushing through a reform of higher education that scientists say will make universities more politicized and less meritocratic.


Feature

In 2013, researchers around the globe published more than 15000 papers on single-layer graphite, called graphene, a number that has grown exponentially since the material was invented 11 years ago. And for good reason: Graphene is the thinnest material ever made. It’s 100 times stronger than steel, a better electrical and heat conductor than copper, flexible, and largely transparent. Investigators envision a future for it in everything from the next generation of computer chips and flexible displays to batteries and fuel cells. But graphene has drawbacks, especially its inability to act as a semiconductor. Now, chemists and materials scientists are striving to move beyond graphene. They’re synthesizing other two-dimensional sheetlike materials that promise to combine flexibility and transparency with electronic properties graphene can’t match. And they are already turning some of them into thin, flexible, speedy electronic and optical devices that they hope will form the backbone of industries of the future.

Science takes a look at the science on Jeopardy!—and the scientists who have won big on the popular TV program. This “smart person’s game show” has for many decades offered clues that require answers in the form of questions, and many of those clues explore the history of science or cutting-edge research. The show’s writers carefully research the science clues so there is no more than one correct response—but sometimes contestants prove them wrong. Among the many scientists who have won multiple times on the show are the new CEO of AAAS (publisher of Science) and a bioinformaticist who set a single game record when he won $77,000. Bonus material for the story (found at http://scim.ag/jeopaRdy) includes a science quiz, a video on one contestant’s winning strategy, and a compilation of research papers about Jeopardy!.

Time to cue the Jeopardy! theme. With help from the kind folks at the game show, we’ve compiled a quiz with 10 clues from past episodes for your entertainment. You can take quiz here or go to http://scim.ag/jeopaRdy for an interactive and timed version that provides more detailed answers. You will also find a video in which Roger Craig, a bioinformaticist who earned a record $77,000 on a single Jeopardy! game and won multiple times, explains how he analyzed an archive of past episodes to strengthen his game skills and identify smart strategic moves. Finally, we offer online a list of research papers about Jeopardy!.


Sponsored by SLAS


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