Science Express Notification for 26 June 2015

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New Science / AAAS Webinar Improving Tissue-Sample Profiling: The Optimization and Application of Immunohistochemistry Tuesday, July 7, 2015, at 12 noon Eastern, 9 a.m. Pacific, 5 p.m. UK (BST), 6 p.m. Central Europe (CEST) Understanding the basic principles underlying IHC and how to address the technical aspects of experimental design are key to producing high-quality, reproducible data. In this webinar, we will hear from experts who will share their insights into assay design. Register TODAY: webinar.sciencemag.org Produced by the Science/AAAS Custom Publishing Office and sponsored by EMD Millipore. Science Science Express   06/26/15 Volume 348, Issue 6242 New Science Express articles have been made available: Reports A protein fold switch joins the circadian oscillator to clock output in cyanobacteria Yong-Gang Chang et al. Atomic-scale origins of slowness in the cyanobacterial circadian clock Jun Abe et al. Natural light-gated anion channels: A family of microbial rhodopsins for advanced optogenetics Elena G. Govorunova et al. Effect of the cytoplasmic domain on antigenic characteristics of HIV-1 envelope glycoprotein Jia Chen et al. Reverse glacier motion during iceberg calving and the cause of glacial earthquakes T. Murray et al. Morphinan biosynthesis in opium poppy requires a P450-oxidoreductase fusion protein Thilo Winzer et al. New Science / AAAS Webinar Improving Tissue-Sample Profiling: The Optimization and Application of Immunohistochemistry Tuesday, July 7, 2015, at 12 noon Eastern, 9 a.m. Pacific, 5 p.m. UK (BST), 6 p.m. Central Europe (CEST) Understanding the basic principles underlying IHC and how to address the technical aspects of experimental design are key to producing high-quality, reproducible data. In this webinar, we will hear from experts who will share their insights into assay design. Register TODAY: webinar.sciencemag.org Produced by the Science/AAAS Custom Publishing Office and sponsored by EMD Millipore.

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Table of Contents for 26 June 2015; Vol. 348, No. 6242

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New Science / AAAS Webinar Improving Tissue-Sample Profiling: The Optimization and Application of Immunohistochemistry Tuesday, July 7, 2015, at 12 noon Eastern, 9 a.m. Pacific, 5 p.m. UK (BST), 6 p.m. Central Europe (CEST) Understanding the basic principles underlying IHC and how to address the technical aspects of experimental design are key to producing high-quality, reproducible data. In this webinar, we will hear from experts who will share their insights into assay design. Register TODAY: webinar.sciencemag.org Produced by the Science/AAAS Custom Publishing Office and sponsored by EMD Millipore. Science Table of Contents   06/26/15 Volume 348, Issue 6242 In this week’s issue: Research Summaries This Week in Science Editor summaries of this week’s papers. Editors’ Choice Highlights of the recent literature. Editorial Solving reproducibility Stuart Buck In Brief This week’s section A roundup of weekly science policy and related news. In Depth Infectious Diseases Surviving Ebola survival Kai Kupferschmidt After recovering from Ebola, some patients are struggling with other health problems. Genetics An enhanced view of gene control Elizabeth Pennisi Chromosomal loops and domains help enhancers turn on genes. Optics Breaking the light barrier Robert F. Service Trick for pushing more bits through optical fibers could ease looming “capacity crunch.” Q&A Tapping a nuclear test ban treasure-trove Daniel Clery Treaty chief offers academics surveillance data. Feature The cancer test Jocelyn Kaiser A nonprofit’s effort to replicate 50 top cancer papers is shaking up labs. Mission controller Eric Hand How Alan Stern’s tenacity, drive, and command got a NASA spacecraft to Pluto. Alan Stern’s worldly ventures Eric Hand Golden Spike and Uwingu are two of Stern’s side efforts. Working Life The health of those who study health Rachel Bernstein Letters Applying antibiotics lessons to antivirals David W. Martin Response—Applying antibiotics lessons to antivirals Elena Bekerman and Shirit Einav China legitimizes ivory, again Jinqi Zhan and Qiang Weng Books et al. History of Science The living element Helen Anne Curry Radium played an important, but often forgotten, role in life sciences research in the early 20th century Education Best practices for digital teaching Erin Dolan A handbook for the 21st-century educator Books Received A listing of books received at Science during the week ending 19 June 2015. Policy Forum Scientific Integrity Self-correction in science at work Bruce Alberts et al. Improve incentives to support research integrity Scientific Standards Promoting an open research culture B. A. Nosek et al. Author guidelines for journals could help to promote transparency, openness, and reproducibility ADVERTISEMENT Perspectives Ecology Ecological communities by design James K. Fredrickson Synthetic ecology requires knowledge of how microbial communities function Microbiota Mother’s littlest helpers Katie Hinde and Zachery T. Lewis Breastmilk nourishes the microbes colonizing the neonatal intestinal tract Materials Science Bearing down on hydrogen Graeme J. Ackland Shockwaves are used to turn deuterium into a liquid metal. [Also see Report by Knudson et al.] Biogeochemistry Who can cleave DMSP? Andrew W. B. Johnston A DMSP lyase from an abundant marine eukaryote differs fundamentally from known bacterial enzymes. [Also see Report by Alcolombri et al.] Optics Topology, spin, and light Michael Stone Evanescent solutions to Maxwell’s equations correspond to surface modes with strong spin-momentum locking. [Also see Report by Bliokh et al.] Gene Regulation A HUSH for transgene expression Thijn R. Brummelkamp and Bas van Steensel A protein complex represses genes that insert into heterochromatin. [Also see Report by Tchasovnikarova et al.] Association Affairs Breaking through the polycarbonate ceiling Reviews BMP gradients: A paradigm for morphogen-mediated developmental patterning Ethan Bier and Edward M. De Robertis Research Articles Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts Rajan Jain et al. Identification of the committed cardiomyoblast that retains proliferative potential may inform cardiac regenerative therapeutics. Reports Overcoming Kerr-induced capacity limit in optical fiber transmission E. Temprana et al. Digital back-propagation is used to mitigate light-induced nonlinear effects in optic fiber. Quantum spin Hall effect of light Konstantin Y. Bliokh et al. A theoretical study reveals that quantum effects may manifest in classical optical experiments. [Also see Perspective by Stone] Atomic gold–enabled three-dimensional lithography for silicon mesostructures Zhiqiang Luo et al. Diffusively patterned gold atoms are coated on silicon as a way to chemically pattern complex shapes. Direct observation of an abrupt insulator-to-metal transition in dense liquid deuterium M. D. Knudson et al. Magnetic compression drives an insulator-to-metal transition in dense liquid deuterium. [Also see Perspective by Ackland] Genomic determinants of coral heat tolerance across latitudes Groves B. Dixon et al. In a warming world, existing variation in heat tolerance could help corals beat the heat. A 12 Å carotenoid translocation in a photoswitch associated with cyanobacterial photoprotection Ryan L. Leverenz et al. Large-scale pigment movement accompanies photoactivation of the orange carotenoid protein. Identification of the algal dimethyl sulfide–releasing enzyme: A missing link in the marine sulfur cycle Uria Alcolombri et al. The dimethylsulfoniopropionate lyase of Emiliania huxleyi is part of a large enzyme family involved in the marine sulfur cycle. [Also see Perspective by Johnston] Possible artifacts of data biases in the recent global surface warming hiatus Thomas R. Karl et al. Updated global surface temperature data do not support the notion of a global warming “hiatus.” A parvalbumin-positive excitatory visual pathway to trigger fear responses in mice Congping Shang et al. A newly identified subcortical pathway links visual inputs to the fear center of the brain. A Cas9–guide RNA complex preorganized for target DNA recognition Fuguo Jiang et al. The guide RNA in the CRISPR-Cas immune/editing system is poised to initiate recognition of target DNA. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells Iva A. Tchasovnikarova et al. A haploid genetic screen in human cells identifies an epigenetic silencing complex that regulates heterochromatin formation. [Also see Perspective by Brummelkamp] Factor-dependent processivity in human eIF4A DEAD-box helicase Cuauhtémoc García-García et al. A complex of three protein translation initiation factors is able to unwind messenger RNA continuously and directionally. Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock Yuxiang Zhang et al. A transcription factor that controls both circadian rhythms and metabolism does so through different genomic mechanisms. Technical Comments Comment on “Global diversity and geography of soil fungi” Christopher W. Schadt and Anna Rosling Comment on “Number-space mapping in the newborn chick resembles humans’ mental number line” Madhur Mangalam and Shraddha Madhav Karve Comment on “Number-space mapping in the newborn chick resembles humans’ mental number line” Christopher Harshaw Response to Comments on “Number-space mapping in the newborn chick resembles humans’ mental number line” Rosa Rugani et al. Podcast Science Podcast: 26 June Show On this week’s show: Making metallic hydrogen and a roundup of daily news stories. New Products New Products A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.     About the Cover Also Online: Science Express Daily News Science Careers Science Signaling Science Translational Medicine Recommend to Your Library Podcast Listen now. Latest News Feature: Cancer reproducibility effort faces backlash Final step in sugar-to-morphine conversion deciphered Controversial trial of genetically modified wheat ends in disappointment Why last year’s flu vaccine didn’t work so well Protesters block effort to restart work on controversial Hawaii telescope; 11 arrested ADVERTISEMENT New Science / AAAS Webinar Improving Tissue-Sample Profiling: The Optimization and Application of Immunohistochemistry Tuesday, July 7, 2015, at 12 noon Eastern, 9 a.m. Pacific, 5 p.m. UK (BST), 6 p.m. Central Europe (CEST) Understanding the basic principles underlying IHC and how to address the technical aspects of experimental design are key to producing high-quality, reproducible data. In this webinar, we will hear from experts who will share their insights into assay design. Register TODAY: webinar.sciencemag.org Produced by the Science/AAAS Custom Publishing Office and sponsored by EMD Millipore.

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Table of Contents for 26 June 2015; Vol. 348, No. 6242

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New Science / AAAS Webinar Improving Tissue-Sample Profiling: The Optimization and Application of Immunohistochemistry Tuesday, July 7, 2015, at 12 noon Eastern, 9 a.m. Pacific, 5 p.m. UK (BST), 6 p.m. Central Europe (CEST) Understanding the basic principles underlying IHC and how to address the technical aspects of experimental design are key to producing high-quality, reproducible data. In this webinar, we will hear from experts who will share their insights into assay design. Register TODAY: webinar.sciencemag.org Produced by the Science/AAAS Custom Publishing Office and sponsored by EMD Millipore. Science Table of Contents   06/26/15 Volume 348, Issue 6242 In this week’s issue: Research Summaries This Week in Science Editor summaries of this week’s papers. Editors’ Choice Highlights of the recent literature. Editorial Solving reproducibility Stuart Buck In Brief This week’s section A roundup of weekly science policy and related news. In Depth Infectious Diseases Surviving Ebola survival Kai Kupferschmidt After recovering from Ebola, some patients are struggling with other health problems. Genetics An enhanced view of gene control Elizabeth Pennisi Chromosomal loops and domains help enhancers turn on genes. Optics Breaking the light barrier Robert F. Service Trick for pushing more bits through optical fibers could ease looming “capacity crunch.” Q&A Tapping a nuclear test ban treasure-trove Daniel Clery Treaty chief offers academics surveillance data. Feature The cancer test Jocelyn Kaiser A nonprofit’s effort to replicate 50 top cancer papers is shaking up labs. Mission controller Eric Hand How Alan Stern’s tenacity, drive, and command got a NASA spacecraft to Pluto. Alan Stern’s worldly ventures Eric Hand Golden Spike and Uwingu are two of Stern’s side efforts. Working Life The health of those who study health Rachel Bernstein Letters Applying antibiotics lessons to antivirals David W. Martin Response—Applying antibiotics lessons to antivirals Elena Bekerman and Shirit Einav China legitimizes ivory, again Jinqi Zhan and Qiang Weng Books et al. History of Science The living element Helen Anne Curry Radium played an important, but often forgotten, role in life sciences research in the early 20th century Education Best practices for digital teaching Erin Dolan A handbook for the 21st-century educator Books Received A listing of books received at Science during the week ending 19 June 2015. Policy Forum Scientific Integrity Self-correction in science at work Bruce Alberts et al. Improve incentives to support research integrity ADVERTISEMENT Scientific Standards Promoting an open research culture B. A. Nosek et al. Author guidelines for journals could help to promote transparency, openness, and reproducibility ADVERTISEMENT Perspectives Ecology Ecological communities by design James K. Fredrickson Synthetic ecology requires knowledge of how microbial communities function Microbiota Mother’s littlest helpers Katie Hinde and Zachery T. Lewis Breastmilk nourishes the microbes colonizing the neonatal intestinal tract Materials Science Bearing down on hydrogen Graeme J. Ackland Shockwaves are used to turn deuterium into a liquid metal. [Also see Report by Knudson et al.] Biogeochemistry Who can cleave DMSP? Andrew W. B. Johnston A DMSP lyase from an abundant marine eukaryote differs fundamentally from known bacterial enzymes. [Also see Report by Alcolombri et al.] Optics Topology, spin, and light Michael Stone Evanescent solutions to Maxwell’s equations correspond to surface modes with strong spin-momentum locking. [Also see Report by Bliokh et al.] Gene Regulation A HUSH for transgene expression Thijn R. Brummelkamp and Bas van Steensel A protein complex represses genes that insert into heterochromatin. [Also see Report by Tchasovnikarova et al.] Association Affairs Breaking through the polycarbonate ceiling Reviews BMP gradients: A paradigm for morphogen-mediated developmental patterning Ethan Bier and Edward M. De Robertis Research Articles Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts Rajan Jain et al. Identification of the committed cardiomyoblast that retains proliferative potential may inform cardiac regenerative therapeutics. Reports Overcoming Kerr-induced capacity limit in optical fiber transmission E. Temprana et al. Digital back-propagation is used to mitigate light-induced nonlinear effects in optic fiber. Quantum spin Hall effect of light Konstantin Y. Bliokh et al. A theoretical study reveals that quantum effects may manifest in classical optical experiments. [Also see Perspective by Stone] Atomic gold–enabled three-dimensional lithography for silicon mesostructures Zhiqiang Luo et al. Diffusively patterned gold atoms are coated on silicon as a way to chemically pattern complex shapes. Direct observation of an abrupt insulator-to-metal transition in dense liquid deuterium M. D. Knudson et al. Magnetic compression drives an insulator-to-metal transition in dense liquid deuterium. [Also see Perspective by Ackland] Genomic determinants of coral heat tolerance across latitudes Groves B. Dixon et al. In a warming world, existing variation in heat tolerance could help corals beat the heat. A 12 Å carotenoid translocation in a photoswitch associated with cyanobacterial photoprotection Ryan L. Leverenz et al. Large-scale pigment movement accompanies photoactivation of the orange carotenoid protein. Identification of the algal dimethyl sulfide–releasing enzyme: A missing link in the marine sulfur cycle Uria Alcolombri et al. The dimethylsulfoniopropionate lyase of Emiliania huxleyi is part of a large enzyme family involved in the marine sulfur cycle. [Also see Perspective by Johnston] Possible artifacts of data biases in the recent global surface warming hiatus Thomas R. Karl et al. Updated global surface temperature data do not support the notion of a global warming “hiatus.” A parvalbumin-positive excitatory visual pathway to trigger fear responses in mice Congping Shang et al. A newly identified subcortical pathway links visual inputs to the fear center of the brain. A Cas9–guide RNA complex preorganized for target DNA recognition Fuguo Jiang et al. The guide RNA in the CRISPR-Cas immune/editing system is poised to initiate recognition of target DNA. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells Iva A. Tchasovnikarova et al. A haploid genetic screen in human cells identifies an epigenetic silencing complex that regulates heterochromatin formation. [Also see Perspective by Brummelkamp] Factor-dependent processivity in human eIF4A DEAD-box helicase Cuauhtémoc García-García et al. A complex of three protein translation initiation factors is able to unwind messenger RNA continuously and directionally. Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock Yuxiang Zhang et al. A transcription factor that controls both circadian rhythms and metabolism does so through different genomic mechanisms. Technical Comments Comment on “Global diversity and geography of soil fungi” Christopher W. Schadt and Anna Rosling Comment on “Number-space mapping in the newborn chick resembles humans’ mental number line” Madhur Mangalam and Shraddha Madhav Karve Comment on “Number-space mapping in the newborn chick resembles humans’ mental number line” Christopher Harshaw Response to Comments on “Number-space mapping in the newborn chick resembles humans’ mental number line” Rosa Rugani et al. Podcast Science Podcast: 26 June Show On this week’s show: Making metallic hydrogen and a roundup of daily news stories. New Products New Products A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.     About the Cover Also Online: Science Express Daily News Science Careers Science Signaling Science Translational Medicine Recommend to Your Library Podcast Listen now. Latest News Feature: Cancer reproducibility effort faces backlash Final step in sugar-to-morphine conversion deciphered Controversial trial of genetically modified wheat ends in disappointment Why last year’s flu vaccine didn’t work so well Protesters block effort to restart work on controversial Hawaii telescope; 11 arrested ADVERTISEMENT New Science / AAAS Webinar Improving Tissue-Sample Profiling: The Optimization and Application of Immunohistochemistry Tuesday, July 7, 2015, at 12 noon Eastern, 9 a.m. Pacific, 5 p.m. UK (BST), 6 p.m. Central Europe (CEST) Understanding the basic principles underlying IHC and how to address the technical aspects of experimental design are key to producing high-quality, reproducible data. In this webinar, we will hear from experts who will share their insights into assay design. Register TODAY: webinar.sciencemag.org Produced by the Science/AAAS Custom Publishing Office and sponsored by EMD Millipore.

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Why parrots are such good copycats, a turtle ancestor, and how teeth evolved

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Latest News and Headlines 24 June 2015

Newly identified brain structure may explain why parrots are such good copycats

In surprise, Dutch court orders government to do more to fight climate change

Hot Neptune sports a tail millions of kilometers long

Video: We found its head!

Armored lizard was ancestor of today’s turtles

U.S. chemical regulation reform gets boost as House passes TSCA rewrite

Giddyup! Horses are running faster than ever

Ancient fish sheds light on how teeth evolved

Senate panel approves $2 billion raise for NIH in 2016

In first, a woman will run U.S. nuclear weapons laboratory

Snail-killing worm invades U.S. mainland

E.U. science chief wants to work ERC magic on innovation

No more needles for diabetics?

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Latest from Science News: How vitamin B12 makes pimples pop up

Latest from Science News 06/25/2015 View in browser Become a Subscribing Member» News in Brief How vitamin B12 makes pimples pop up BY Tina Hesman Saey, Jun 24, 2015 02:00 pm Vitamin B12 causes acne by altering metabolism of skin bacteria. Read More Read More» Introducing Newly discovered yeti crab swarms around Antarctic hydrothermal vents BY Sarah Schwartz, Jun 24, 2015 02:00 pm A newly discovered species of yeti crab thrives in tough conditions on Antarctic hydrothermal vents. Read More Read More» How Bizarre Fossil worm adds head to its spiny appearance BY Ashley Yeager, Jun 24, 2015 01:00 pm Hallucigenia sparsa gives hints to how some animals ended up with teeth in their guts and platelike pieces around their mouths. Read More Read More» More Headlines from Science News Wild Things Beauty drives orchids towards extinction Dozens of species of Asian slipper orchids have been newly classified as threatened or endangered, their numbers driven low by illegal trade. Read More By Sarah Zielinski, Jun 23, 2015 12:16 pm News Magnetic ‘glue’ helps shape galaxies Galaxy-wide magnetic fields may play a role in shaping the spiral arms of gas and stars. Read More By Christopher Crockett, Jun 23, 2015 07:30 am Science Ticker Pluto and Charon’s orbital dance captured in color New Horizons has captured the first true-color movie of Pluto and Charon orbiting one another. Read More By Christopher Crockett, Jun 22, 2015 03:00 pm News Sense of smell is strictly personal, study suggests A new test can identify individuals based on their sense of smell, and may hold information about a person’s genetic makeup as well. Read More By Sarah Schwartz, Jun 22, 2015 03:00 pm News Brain’s adult stem cells born early By tracing the lineages of adult stem cells in the mouse brain, scientists get a view of the cells’ early lives. Read More By Laura Sanders, Jun 22, 2015 10:22 am Introducing Silver ant hairs reflect sunlight, keeping Sahara dweller cool The shiny hairs of the Saharan silver ant simultaneously reflect sunlight and permit the release of body heat, keeping the insects just cool enough to scavenge in the extreme summer sun. Read More By Andrew Grant, Jun 22, 2015 07:00 am How Bizarre Big exoplanet may be surrounded by helium Warm Neptune-sized exoplanet might have atmospheres filled with helium. Read More By Christopher Crockett, Jun 21, 2015 03:30 pm Privacy Policy | Update Email Preferences | Unsubscribe from All SSP Newsletters | Contact Us Facebook | Twitter | Vimeo | Google+ Society for Science & the Public • 1719 N Street, N.W. Washington, DC 20036 • Copyright © 2015

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Re: I am thinking about f%cking you

Send me a F#ckFriends request so we can hook up My usename is VeronicaWet09 my profile is here TALK WITH ME

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please f#ck me tonite

Send me a F#ckFriends request so we can hook up My usename is Suck4Fun2 my profile is here SPEAK SOON

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Sci Transl Med Table of Contents for 24 June 2015; Vol. 7, No. 293

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Science/AAAS Webinar New technologies for translational research: Applying high-content screening in cancer research and personalized medicine Learn how high content screening and novel computer modeling are being applied to systems biology, translational cancer research, and personalized medicine. Register to view TODAY: webinar.sciencemag.org Produced by the Science/AAAS Custom Publishing Office and sponsored by PerkinElmer. Science Translational Medicine Table of Contents   06/24/15 Volume 7, Issue 293 <!––> <!– Congratulations to Nicholas Navin from MD Anderson Cancer Center on winning the 2015 AAAS Martin and Rose Wachtel Cancer Research Award, and to the runners up, Agnel Sfeir (NYU) and Nitzan Rosenfeld (Cambridge). –> Did you miss…? Perspective: Developing vaccines for an aging population. <!– Last chance to register for Bridging Biomedical Worlds “From Neural Circuitry to Neurotechnology” in Tokyo. –> <!– Science Translational Medicine welcomes our 2015 Associate Scientific Advisors. –> <!– The focus of this week’s issue is cancer to coincide with the AACR annual meeting –> In this week’s issue: Research Articles CANCER Epigenetic therapy overcomes treatment resistance in T cell prolymphocytic leukemia Zainul S. Hasanali et al. Epigenetic drugs can overcome resistance to monoclonal antibodies in T-PLL and activate therapeutic targets for antibody-drug conjugates. MICROBIOTA Vitamin B12 modulates the transcriptome of the skin microbiota in acne pathogenesis Dezhi Kang et al. Vitamin B12 modulates the transcriptional activities of the skin microbiota, leading to acne development. CANCER Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas Yuxuan Wang et al. Tumor DNA in saliva and plasma can provide a noninvasive biomarker for head and neck squamous cell carcinoma. Perspective DRUG DISCOVERY Developing predictive assays: The phenotypic screening “rule of 3” Fabien Vincent et al. Not all phenotypic assays are created equal; critically evaluating the disease relevance of the assay system, stimulus, and readout can help design the most predictive ones. Podcast CANCER Science Translational Medicine Podcast: 24 June 2015 Nishant Agrawal and Annalisa VanHook Nishant Agrawal talks about detecting tumor DNA in saliva and plasma of patients with head and neck cancers. Editors’ Choice HEARING IMPAIRMENT Screen time Pamela Bhatti An interactive, tablet-based screening tool demonstrates predictive value for hearing loss in children. INFLUENZA Mixing it up Nicole M. Bouvier The genome reassortment among influenza A viruses that can lead to pandemics may be more common than we thought. VIROLOGY Going viral Biju Parekkadan A multiplexed assay using a synthetic peptide library enabled population analysis of historical immunization to viral infections in humans. AMYOTROPHIC LATERAL SCLEROSIS Elucidating the role of C9orf72 mutations in ALS Jeffrey Statland Conditional knockdown of C9orf72 in mice does not cause loss of motor function or decrease survival, arguing against a loss-of-function role for C9orf72 in ALS. CANCER Genes and lung cancer: Stop YAPping! Anish Thomas A highly penetrant germline mutation of YAP1 oncogene predisposes to lung adenocarcinoma, and mutation carriers may benefit from increased surveillance. GENE THERAPY Baby steps in gene therapy Deniz Dalkara Teaching the immune system tolerance to a missing protein in neonates improves safety and efficacy of gene replacement therapy.     Also Online: Current Issue Archives About STM Information for Authors Recommend to Your Library Science/AAAS Webinar New technologies for translational research: Applying high-content screening in cancer research and personalized medicine Learn how high content screening and novel computer modeling are being applied to systems biology, translational cancer research, and personalized medicine. Register to view TODAY: webinar.sciencemag.org Produced by the Science/AAAS Custom Publishing Office and sponsored by PerkinElmer.

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Latest News and Headlines 23 June 2015

Senate panel approves $2 billion raise for NIH in 2016

In first, a woman will run U.S. nuclear weapons laboratory

Snail-killing worm invades U.S. mainland

E.U. science chief wants to work ERC magic on innovation

No more needles for diabetics?

Video: Young beetles pump their abs to breathe

Plundering a nuclear test ban treasure-trove

Japan still mulling lethal research whaling

Astronomers to restart construction of controversial telescope in Hawaii

In setback for potential Ebola drug, company halts trial

Glowing diamonds make great thermometers

Vulture populations plummet across Africa

Top stories: The universe’s first stars, Philae’s wake-up call, and dinosaur exile

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Science Signaling Table of Contents for 23 June 2015; Volume 8, Issue 382

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Sponsored by the Science / AAAS Custom Publishing Office Watch Previously Recorded Webinars from Science / AAAS View our collection of over 50 webinars on webinar.sciencemag.org and learn how today’s research is shaping tomorrow’s discoveries. Featuring presentations from world renowned experts on a broad range of topics, including Noncoding RNAs, Imaging, Apoptosis, qPCR, Next-Gen Sequencing, and Stem Cell Research, the webinars are a tremendous learning tool that include previously recorded question and answer segments. Watch Science Webinars today at webinar.sciencemag.org. Science Signaling Table of Contents   06/23/15 Volume 8, Issue 382 <!––> Check out the new look of the journal! <!– –> In this week’s issue: Research Articles Neuroepigenetics DNA methylation regulates neuronal glutamatergic synaptic scaling Jarrod P. Meadows et al. Epigenetically mediated changes in postsynaptic glutamate receptor expression enable neurons to adjust responsiveness to their environment. Stress Response IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions Kohsuke Kanekura et al. The kinase activity of IRE1 prevents cell death triggered by permeabilization of the ER by Bax and Bak. Drug Discovery Identification of small-molecule inhibitors of calcineurin-NFATc signaling that mimic the PxIxIT motif of calcineurin binding partners Minos-Timotheos Matsoukas et al. Finding compounds that target a specific phosphatase-substrate interaction may yield immunosuppressive drugs with fewer side effects. Podcasts Neuroepigenetics Science Signaling Podcast: 23 June 2015 David J. Sweatt et al. DNA methylation controls glutamatergic synaptic scaling, a type of synaptic plasticity important for learning and memory. Editors’ Choice Immunology From tissue damage to adaptive immunity Annalisa M. VanHook Vertebrate adaptive immunity may have evolved from the innate response to tissue damage. Immunology Recruiting bystanders to fight infection Sudhakaran Prabakaran Infected and uninfected immune cells collaborate to mount an immune response. Cancer Immunology Metastatic trio: Macrophages, neutrophils, and γδ T cells Nancy R. Gough Metastasis of breast cancer cells involves a complex interaction among many types of immune cells. Cancer Critical feedback against bone metastasis Leslie K. Ferrarelli Loss of a negative feedback regulator enables TGF-β signaling to promote prostate cancer metastasis to the bone. Cell Biology Ensuring daughter cells get PCP components Annalisa M. VanHook A mitotic kinase ensures even distribution of planar cell polarity components to daughter cells. Pharmacology Improving ER function Kelly LaMarco Assays that measure endoplasmic reticulum (ER) function identify a small molecule, azoramide, with antidiabetic effects. Structural Biology How a receptor transmits a signal Valda Vinson Atomic-level simulations show how G protein–coupled receptors trigger G protein signaling. Cancer A degrading game plan for cancer therapy Paula A. Kiberstis A chemical strategy that leads to selective destruction of proteins of interest may be a valuable tool for drug development. Also Online: Current Issue Archives About Science Signaling Information for Authors Recommend to Your Library Sponsored by the Science / AAAS Custom Publishing Office Watch Previously Recorded Webinars from Science / AAAS View our collection of over 50 webinars on webinar.sciencemag.org and learn how today’s research is shaping tomorrow’s discoveries. Featuring presentations from world renowned experts on a broad range of topics, including Noncoding RNAs, Imaging, Apoptosis, qPCR, Next-Gen Sequencing, and Stem Cell Research, the webinars are a tremendous learning tool that include previously recorded question and answer segments. Watch Science Webinars today at webinar.sciencemag.org.

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