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New complimentary webinar from Science: Improving tissue-sample profiling: The optimization and application of immunohistochemistry You are invited to hear our panel of experts on July 7, 2015, in this live, online educational seminar. For more information and complimentary registration visit: webinar.sciencemag.org Date: Tuesday, July 7, 2015 Time: 12 noon Eastern, 9 a.m. Pacific, 5 p.m. UK, 6 p.m. Central Europe Duration: 1 hour About This Webinar Though it has been used for more than 70 years, immunohistochemistry (IHC) is still an essential research and diagnostic tool in many scientific laboratories. Understanding the basic principles underlying IHC and how to address the technical aspects of experimental design are key to producing high-quality, reproducible data. IHC is used in a variety of fields— from cancer diagnostics to neuroscience research—but some common advice can be applied across-the-board. Many variables are vital for generating valuable results and require optimization when designing IHC experiments, such as fixing tissue, choosing the proper antibodies, and defining the proper controls. In this webinar, we will hear from experts who will share their insights into the key aspects of assay design. During the webinar, the speakers will: • Provide an overview of their immunohistochemistry methods • Highlight some best practices and common challenges in assay design • Discuss the applications of IHC in cancer research and neuroscience • Answer your questions live during the broadcast! <!– • Have their questions answered live by the panelists! –> Participants: Nissi M. Varki, M.D. University of California San Diego La Jolla, CA Kevin D. Long, Ph.D. EMD Millipore Temecula, CA <!– Giridharan Periyasamy, Ph.D. Genome Institute of Singapore Singapore, Malaysia –> Register at: webinar.sciencemag.org Questions? E-mail: webinar@aaas.org. Produced by the Science/AAAS Custom Publishing Office and sponsored by EMD Millipore.

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Science Signaling Table of Contents for 30 June 2015; Volume 8, Issue 383

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Sponsored by the Science / AAAS Custom Publishing Office Watch Previously Recorded Webinars from Science / AAAS View our collection of over 50 webinars on webinar.sciencemag.org and learn how today’s research is shaping tomorrow’s discoveries. Featuring presentations from world renowned experts on a broad range of topics, including Noncoding RNAs, Imaging, Apoptosis, qPCR, Next-Gen Sequencing, and Stem Cell Research, the webinars are a tremendous learning tool that include previously recorded question and answer segments. Watch Science Webinars today at webinar.sciencemag.org. Science Signaling Table of Contents   06/30/15 Volume 8, Issue 383 Did you miss the Focus Issue on Inflammatory Mechanisms? <!– –> In this week’s issue: Research Articles DNA Damage The kinase ABL phosphorylates the microprocessor subunit DGCR8 to stimulate primary microRNA processing in response to DNA damage Chi-Chiang Tu et al. DNA damage triggers the biogenesis of some miRNAs through the activity of the kinase ABL. Developmental Neuroscience WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons Perrine Friedel et al. Immature neurons need WNK1-dependent phosphorylation of KCC2 to prevent a premature switch in the Cl− gradient and the effect of GABA. Synthetic Biology Simple synthetic protein scaffolds can create adjustable artificial MAPK circuits in yeast and mammalian cells Jihoon Ryu and Sang-Hyun Park Designer scaffolds reveal the minimal requirements of engineered MAPK scaffolds. Podcasts Developmental Neuroscience Science Signaling Podcast: 30 June 2015 Kristopher T. Kahle and Annalisa M. VanHook WNK1-dependent phosphorylation of an ion transporter ensures that immature neurons are stimulated, rather than inhibited, by the neurotransmitter GABA. Editors’ Choice Cancer Treating cancer pain Leslie K. Ferrarelli Inhibiting vascular endothelial growth factor signaling may decrease pain sensitivity in cancer patients. Physiology ER trap for blood pressure control Nancy R. Gough Cancer Bacterial-induced transformation Annalisa M. VanHook Salmonella infection triggers signaling events that increase the probability of developing cancer in hosts that are genetically predisposed to transformation. Plant Biology Competing for stomata Annalisa M. VanHook Two structurally related peptides compete for binding to the same receptor to control the density of stomata on leaves. Microbiology Vitamin B12 contributes to acne by affecting the skin microbiota Angela Colmone Vitamin B12 stimulates the transcription of genes that promote inflammation from the skin microbiota. Circadian Biology Multitasking around the clock Paula A. Kiberstis A transcription factor that controls both circadian rhythms and metabolism does so through different genomic mechanisms. Cardiac Physiology Making cardiomyocytes Beverly A. Purnell Identification of the committed cardiomyoblast that retains proliferative potential may inform cardiac regenerative therapeutics. Also Online: Current Issue Archives About Science Signaling Information for Authors Recommend to Your Library Sponsored by the Science / AAAS Custom Publishing Office Watch Previously Recorded Webinars from Science / AAAS View our collection of over 50 webinars on webinar.sciencemag.org and learn how today’s research is shaping tomorrow’s discoveries. Featuring presentations from world renowned experts on a broad range of topics, including Noncoding RNAs, Imaging, Apoptosis, qPCR, Next-Gen Sequencing, and Stem Cell Research, the webinars are a tremendous learning tool that include previously recorded question and answer segments. Watch Science Webinars today at webinar.sciencemag.org.

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