Science Express Notification for 24 July 2015

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New Science/AAAS Webinar Generating the best superresolution microscopy data: Finding the right tool for the right job Wednesday, July 29, 2015, at 9 a.m. Pacific, 12 noon Eastern, 5 p.m. UK, 6 p.m. Central Europe Join our roundtable discussion with microscopy experts Nobel laureate Eric Betzig, Raman Das, and Justin Taraska. Register TODAY: webinar.sciencemag.org Produced by the Science/AAAS Custom Publishing Office and sponsored by GE Healthcare. Science Science Express   07/24/15 Volume 349, Issue 6246 New Science Express articles have been made available: Research Articles Abrupt warming events drove Late Pleistocene Holarctic megafaunal turnover Alan Cooper et al. Reports CERAMIC FUEL CELLS Readily processed protonic ceramic fuel cells with high performance at low temperatures Chuancheng Duan et al. Voltage-tunable circular photogalvanic effect in silicon nanowires Sajal Dhara et al. RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself Brian J. Liddicoat et al. New Science/AAAS Webinar Generating the best superresolution microscopy data: Finding the right tool for the right job Wednesday, July 29, 2015, at 9 a.m. Pacific, 12 noon Eastern, 5 p.m. UK, 6 p.m. Central Europe Join our roundtable discussion with microscopy experts Nobel laureate Eric Betzig, Raman Das, and Justin Taraska. Register TODAY: webinar.sciencemag.org Produced by the Science/AAAS Custom Publishing Office and sponsored by GE Healthcare.

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Cataract-dissolving eyedrops, safer estrogen therapy, & refueling a galaxy

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Latest News and Headlines 22 July 2015

Eye drops could dissolve cataracts

Senator offers tantalizing prospect of regulatory relief for biomedical researchers

A safer estrogen therapy for women?

New rice variety could feed the planet without warming it

Autism rates are up, but is the disease really on the rise?

Telescope spots galaxy refueling in the early universe

Climate researcher blasts global warming target as highly dangerous

Biochemists launch crowdsourcing site to combat bad data

Mysterious link emerges between Native Americans and people half a globe away

Scientists arm cells with tiny lasers

Great Recession was good for the environment

The benefits of band class

Shark attacks: Is it safe to go back in the water?

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Latest from Science News: Boas kill by cutting off blood flow, not airflow

Latest from Science News 07/23/2015 View in browser Become a Subscribing Member» Science Ticker Boas kill by cutting off blood flow, not airflow BY Ashley Yeager, Jul 22, 2015 06:00 pm Boas actually kill by constricting blood flow of their prey, not suffocating them, as scientists previously suspected. Read More Read More» News Boosting estrogen, only in the brain BY Sarah Schwartz, Jul 22, 2015 05:32 pm Scientists have developed a chemical that transforms into the hormone estrogen in the brain, but not the body, of rats. Read More Read More» Wild Things Sea level rise threatens sea turtles BY Sarah Zielinski, Jul 22, 2015 04:00 pm Sea level rise is causing coastal areas to be inundated with water. Even short periods of being wet can kill sea turtle eggs, a new study finds. Read More Read More» More Headlines from Science News Wild Things Eyewitness account of a dolphin birth takes a dark turn Scientists witnessed the first wild birth of a bottlenose dolphin — and an attempt at infanticide. Read More By Sarah Zielinski, Jul 21, 2015 11:17 am News Death by brain-eating amoeba is an inside job Immune response to brain-eating amoeba may be the real killer. Read More By Laura Sanders, Jul 20, 2015 07:28 pm News in Brief Search for E.T. gets financial boost Search for extraterrestrial intelligence gets a $100 million donation from a Russian entrepreneur. Read More By Christopher Crockett, Jul 20, 2015 05:45 pm News Breakdown of Alzheimer’s protein slows with age It takes longer to get rid of an Alzheimer’s-associated protein with age. Read More By Tina Hesman Saey, Jul 20, 2015 04:28 pm News Carbon dating may soon lead to mismatches Carbon released from burning fossil fuels will jeopardize the effectiveness of many carbon dating applications, new research predicts. Read More By Thomas Sumner, Jul 20, 2015 03:06 pm News Biology may provide just the right chemistry for new drugs Using enzymes and microbes to make new drugs may help revive the pharmaceutical industry. Read More By Beth Mole, Jul 20, 2015 09:57 am Scicurious The weekly grind of social jetlag could be a weighty issue Even those of us with nine-to-five jobs don’t always respect our body’s clocks. Research shows that even slight disruptions might be associated with obesity. Read More By Bethany Brookshire, Jul 20, 2015 07:38 am Privacy Policy | Update Email Preferences | Unsubscribe from All SSP Newsletters | Contact Us Facebook | Twitter | Vimeo | Google+ Society for Science & the Public • 1719 N Street, N.W. Washington, DC 20036 • Copyright © 2015

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Sci Transl Med Table of Contents for 22 July 2015; Vol. 7, No. 297

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Sponsored by the Science/AAAS Custom Publishing Office Watch Previously Recorded Webinars from Science/AAAS View our collection of over 50 webinars on webinar.sciencemag.org and learn how today’s research is shaping tomorrow’s discoveries. Featuring presentations from world renowned experts on a broad range of topics, including Noncoding RNAs, Imaging, Apoptosis, qPCR, Next-Gen Sequencing, and Stem Cell Research, the webinars are a tremendous learning tool that include previously recorded question and answer segments. Watch Science Webinars today at webinar.sciencemag.org. Science Translational Medicine Table of Contents   07/22/15 Volume 7, Issue 297 Join Science Translational Medicine at ITMAT 2015 Systems Pharmacology and Translational Therapeutics in Philadelphia, PA. Oct 12-13 Join us for the AAAS Martin and Rose Wachtel Cancer Research Award Ceremony at the National Institutes of Health and hear winner Nicholas Navin talk about his research on single-cell DNA analysis. <!– Last chance to register for Bridging Biomedical Worlds “From Neural Circuitry to Neurotechnology” in Tokyo. –> <!– Science Translational Medicine welcomes our 2015 Associate Scientific Advisors. –> <!– The focus of this week’s issue is cancer to coincide with the AACR annual meeting –> In this week’s issue: Research Articles NEUROLOGY The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders Laszlo Prokai et al. The bioprecursor prodrug 10β, 17β-dihydroxyestra-1,4-dien-3-one (DHED) allows 17β-estradiol to form in the female brain for neuroprotection and to treat neurological and psychiatric symptoms of menopause. DRUG RESISTANCE Fitness cost of antibiotic susceptibility during bacterial infection Damien Roux et al. The quest to stem antibiotic resistance might be exacerbated by enhanced fitness and virulence displayed by the drug-resistant microbes. HUMAN IMMUNOLOGY Human NK cell repertoire diversity reflects immune experience and correlates with viral susceptibility Dara M. Strauss-Albee et al. Human natural killer cell diversity is a metric of immune function associated with less effective antiviral response. RETINAL DEGENERATION Inhibition of the alternative complement pathway preserves photoreceptors after retinal injury J. Harry Sweigard et al. The alternative complement pathway is activated in response to retinal injury, and inhibiting this pathway prevents complement-mediated photoreceptor cell death. Editorial TECHNOLOGY App-enabled trial participation: Tectonic shift or tepid rumble? Stephen H. Friend App-enabled clinical trials can transform our view of health, disease, and translational research. Focus BIOBANKS Optimizing sharing of hospital biobank samples Peter H. J. Riegman et al. Implementing technical guidelines and standards as well as ways to boost cooperation should facilitate sharing of hospital biobank samples. Editors’ Choice CYSTIC FIBROSIS Inspirational genes Marshaleen Henriques-Forsythe This study investigated the impact of nebulized nonviral gene therapy on lung function in cystic fibrosis patients. TRAUMATIC BRAIN INJURY Add ARBs to injury? Yo-El Ju With an experimental design that mimics the dose and timing possible in patients, angiotensin receptor blockers improve recovery after traumatic brain injury in mice. HUMAN GENETICS Fresh AIRE for autoimmune disease genetics Alexander Marson New evidence highlights heterozygous mutations in AIRE, with dominant negative effects causing loss of tolerance and organ-specific autoimmunity. WOUND REPAIR Speedy repair with stabilized β-catenin Tanya J Shaw CXXC5 inhibition is a novel strategy to stabilize β-catenin and, in turn, accelerate wound healing. GENOMICS Diverse diseases, diverse variants Masako Suzuki The disease-associated variants within different disease categories are preferentially targeted to specific regulatory elements. Letter TRANSPLANTATION Comment on “Tracking donor-reactive T cells: Evidence for clonal deletion in tolerant kidney transplant patients” Guy Gorochov et al. Difficulties in tracking of bona fide alloreactive clones may limit understanding of the mechanisms of spontaneous tolerance. TRANSPLANTATION Author response to comment on “Tracking donor-reactive T cells: Evidence for clonal deletion in tolerant kidney transplant patients” Susan DeWolf et al. Difficulties in tracking of bona fide alloreactive clones may limit understanding of the mechanisms of spontaneous tolerance.     Also Online: Current Issue Archives About the Journal Information for Authors Recommend to Your Library Sponsored by the Science/AAAS Custom Publishing Office Watch Previously Recorded Webinars from Science/AAAS View our collection of over 50 webinars on webinar.sciencemag.org and learn how today’s research is shaping tomorrow’s discoveries. Featuring presentations from world renowned experts on a broad range of topics, including Noncoding RNAs, Imaging, Apoptosis, qPCR, Next-Gen Sequencing, and Stem Cell Research, the webinars are a tremendous learning tool that include previously recorded question and answer segments. Watch Science Webinars today at webinar.sciencemag.org.

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Scientists implant lasers into cells, why playing music is good for you, & more

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Latest News and Headlines 21 July 2015

Biochemists launch crowdsourcing site to combat bad data

Mysterious link emerges between Native Americans and people half a globe away

Scientists arm cells with tiny lasers

Great Recession was good for the environment

The benefits of band class

Shark attacks: Is it safe to go back in the water?

Society asks NIH to act now to lessen biomed scientist glut

Video: Battle wound may reveal bones of Alexander the Greats father

How a young child fought off the AIDS virus

Arctic sea ice enjoyed a brief—but temporary—respite from melting in 2013

Internet tycoon takes search for extraterrestrial intelligence to the next level

Potential geysers spotted on Pluto

Top stories: Pluto is alive, Big Bird the dinosaur, and buckyballs in space

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Latest from Science News: Research teams duel over Native American origins

Latest from Science News 07/21/2015 View in browser Become a Subscribing Member» News Research teams duel over Native American origins BY Tina Hesman Saey, Jul 21, 2015 01:00 pm Genetic link between Australia and the Amazon fuels two interpretations of Native American origins. Read More Read More» Wild Things Eyewitness account of a dolphin birth takes a dark turn BY Sarah Zielinski, Jul 21, 2015 11:17 am Scientists witnessed the first wild birth of a bottlenose dolphin — and an attempt at infanticide. Read More Read More» News Death by brain-eating amoeba is an inside job BY Laura Sanders, Jul 20, 2015 07:28 pm Immune response to brain-eating amoeba may be the real killer. Read More Read More» More Headlines from Science News News Biology may provide just the right chemistry for new drugs Using enzymes and microbes to make new drugs may help revive the pharmaceutical industry. Read More By Beth Mole, Jul 20, 2015 09:57 am Scicurious The weekly grind of social jetlag could be a weighty issue Even those of us with nine-to-five jobs don’t always respect our body’s clocks. Research shows that even slight disruptions might be associated with obesity. Read More By Bethany Brookshire, Jul 20, 2015 07:38 am News in Brief Latest dispatch from Pluto reveals frozen plains, icy hills and more Polygon plains, windswept hydrocarbons, and more moons were tantalizing details revealed about Pluto in the latest data from New Horizons. Read More By Christopher Crockett, Jul 17, 2015 03:39 pm Science Ticker Blooming phytoplankton seed clouds in the Southern Ocean Booming phytoplankton populations spark cloud formation in the Southern Ocean. Read More By Beth Mole, Jul 17, 2015 02:00 pm Science Ticker Mosquitoes can get a double dose of malaria Carrying malaria may make mosquitoes more susceptible to infection with a second strain of the parasite that causes the disease. Read More By Tina Hesman Saey, Jul 17, 2015 11:44 am Science Ticker Bundles of cells hint at biological differences of autistic brains Using miniature organoids that mimic the human brain, scientists have identified developmental differences between autistic children and their non-autistic family members. Read More By Sarah Schwartz, Jul 17, 2015 09:20 am News in Brief Polar bears’ ‘walking hibernation’ not much of an energy saver Summer’s “walking hibernation” doesn’t shut down polar bears as much as winter does. Read More By Susan Milius, Jul 16, 2015 03:17 pm Privacy Policy | Update Email Preferences | Unsubscribe from All SSP Newsletters | Contact Us Facebook | Twitter | Vimeo | Google+ Society for Science & the Public • 1719 N Street, N.W. Washington, DC 20036 • Copyright © 2015

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Science Signaling Table of Contents for 21 July 2015; Volume 8, Issue 386

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New Science/AAAS and Science Signaling Webinar Part 4: Targeting Cancer Pathways: The Epigenetics Question Wednesday, August 12, 2015, at 9 a.m. Pacific, 12 noon Eastern, 5 p.m. UK, 6 p.m. Central Europe What is the role of epigenetics in cancer? Watch this webinar to find out what leaders in the field have found. Register TODAY: webinar.sciencemag.org Produced by the Science/AAAS Custom Publishing Office and sponsored by Cell Signaling Technology. Science Signaling Table of Contents   07/21/15 Volume 8, Issue 386 Sign up for “Part 4: Targeting Cancer Pathways—The Epigenetics Question”, a webinar hosted by Science Signaling web editor Annalisa VanHook and featuring Stephen B. Baylin, Charles Roberts, and Ali Shilatifard. <!– –> In this week’s issue: Focus Physiology A top-notch dilemma: The complex role of NOTCH signaling in osteoarthritis Anusha Ratneswaran and Frank Beier Whether NOTCH signaling induces maintenance or degradation of joint cartilage depends on signal strength and duration. Research Articles Physiology A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis Zhaoyang Liu et al. NOTCH can protect joints or exacerbate joint injury depending on signal strength and duration and context. Cardiac Physiology Protein phosphatase 2A regulatory subunit B56α limits phosphatase activity in the heart Sean C. Little et al. Targeting a regulatory subunit in the phosphatase PP2A could limit arrhythmias caused by excessive adrenergic stimulation. Metabolism Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2 Rocio Vila-Bedmar et al. Inhibiting a protein involved in insulin and adrenergic signaling may improve metabolic disorders. Podcasts Metabolism Science Signaling Podcast: 21 July 2015 Rocio Vila-Bedmar et al. Removing the kinase GRK2 prevents some of the metabolic consequences of a high-fat diet. Editors’ Choice Microbiology Cyclin-like function of bacterial c-di-GMP Annalisa M. VanHook The bacterial second messenger c-di-GMP controls cell cycle progression. Neuroscience Addiction by Activin Leslie K. Ferrarelli Activin signaling mediates changes in neuronal spine density, thereby contributing to addiction. Cancer Mitochondria power drug-induced invasion Sudhakaran Prabakaran Redistribution of mitochondria to the cortex contributes to the enhanced invasive phenotype of cancer cells exposed to phosphoinositide 3-kinase inhibitors. Cell Biology Degron for autophagic disposal Nancy R. Gough N-terminal arginylated cytosolically localized ER proteins function as adaptors delivering cargo destined for autophagy. Immunology Neutrophil NETs drive atherosclerosis Kristen L. Mueller Neutrophils release networks of extracellular fibers that contribute to the pathogenesis of atherosclerosis. Circadian Biology Biochemical basis of a 24-hour clock L. Bryan Ray A slow adenosine triphosphatase reaction in a clock protein combined with a slow conformational change in another clock protein sets the pace of a circadian clock. Also Online: Current Issue Archives About Science Signaling Information for Authors Recommend to Your Library New Science/AAAS and Science Signaling Webinar Part 4: Targeting Cancer Pathways: The Epigenetics Question Wednesday, August 12, 2015, at 9 a.m. Pacific, 12 noon Eastern, 5 p.m. UK, 6 p.m. Central Europe What is the role of epigenetics in cancer? Watch this webinar to find out what leaders in the field have found. Register TODAY: webinar.sciencemag.org Produced by the Science/AAAS Custom Publishing Office and sponsored by Cell Signaling Technology.

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Science Express Notification for 21 July 2015

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New Science/AAAS Webinar Generating the best superresolution microscopy data: Finding the right tool for the right job Wednesday, July 29, 2015, at 9 a.m. Pacific, 12 noon Eastern, 5 p.m. UK, 6 p.m. Central Europe Join our roundtable discussion with microscopy experts Nobel laureate Eric Betzig, Raman Das, and Justin Taraska. Register TODAY: webinar.sciencemag.org Produced by the Science/AAAS Custom Publishing Office and sponsored by GE Healthcare. Science Science Express   07/21/15 Volume 349, Issue 6245 New Science Express articles have been made available: Research Article Genomic evidence for the Pleistocene and recent population history of Native Americans Maanasa Raghavan et al. New Science/AAAS Webinar Generating the best superresolution microscopy data: Finding the right tool for the right job Wednesday, July 29, 2015, at 9 a.m. Pacific, 12 noon Eastern, 5 p.m. UK, 6 p.m. Central Europe Join our roundtable discussion with microscopy experts Nobel laureate Eric Betzig, Raman Das, and Justin Taraska. Register TODAY: webinar.sciencemag.org Produced by the Science/AAAS Custom Publishing Office and sponsored by GE Healthcare.

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Re: want to be my new f#ckbuddy

Send me a F#ckFriends request so we can hook up My usename is Cowboy957 my profile is here SEE YOU SOON

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please f#ck me tonite

Send me a F#ckFriends request so we can hook up My usename is SweetTart198 my profile is here SEE YOU SOON

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