Science Express Notification for 28 August 2015

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New Science/AAAS Webinar Advancing precision medicine through multi-omics: An integrated approach to tumor profiling Wednesday, September 16, 2015, at 9 a.m. Pacific, 12 noon Eastern, 5 p.m. UK, 6 p.m. Central Europe Hear the experts discuss how a multi-omics approach to cancer research can advance our understanding of cancer biology and uncover new biomarkers. Register TODAY: webinar.sciencemag.org Produced by the Science/AAAS Custom Publishing Office and sponsored by Affymetrix. Science Science Express   08/28/15 Volume 349, Issue 6251 New Science Express articles have been made available: Research Articles A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen Antonietta Impagliazzo et al. STRUCTURAL BIOLOGY Architecture of the fungal nuclear pore inner ring complex Tobias Stuwe et al. Reports H-BONDING CATALYSIS O–H Hydrogen bonding promotes H-atom transfer from α C–H bonds for C-alkylation of alcohols Jenna L. Jeffrey et al. New Science/AAAS Webinar Advancing precision medicine through multi-omics: An integrated approach to tumor profiling Wednesday, September 16, 2015, at 9 a.m. Pacific, 12 noon Eastern, 5 p.m. UK, 6 p.m. Central Europe Hear the experts discuss how a multi-omics approach to cancer research can advance our understanding of cancer biology and uncover new biomarkers. Register TODAY: webinar.sciencemag.org Produced by the Science/AAAS Custom Publishing Office and sponsored by Affymetrix.

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Antibiotic resistance, crayfish ‘superclones’ & more

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News from Science

Latest News and Headlines 26 August 2015

African wildlife harbors resistance to first-line antibiotics

Crayfish create a new species of female ‘superclones’

Tugging, pushing deep within Earth may explain mysterious earthquakes

Plugged pores may cause dementia, other neurological diseases

Fighting wildlife smuggling, one DNA test at a time

What the microbes in your home say about you

Orchids’ dazzling diversity explained

In brief, papers with shorter titles get more citations, study suggests

‘Winged monster’ on ancient rock art debunked by scientists

Death metal in ancient oceans

Exclusive: Secretive fusion company claims reactor breakthrough

How does the new ‘female Viagra’ work?

QA: How the Franco dictatorship destroyed Spanish science

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Latest from Science News: Hawking proposes solution to black hole problem

Latest from Science News 08/27/2015 View in browser Become a Subscribing Member» News Hawking proposes solution to black hole problem BY Andrew Grant, Aug 26, 2015 05:17 pm Light sliding along the boundary of a black hole encodes everything that ever fell inside, suggests Stephen Hawking in a new but incomplete proposal. Read More Read More» Science Ticker Earlier is better for HIV treatment BY Nathan Seppa, Aug 26, 2015 05:00 pm People infected with HIV benefit from starting a drug regimen early, an international study finds. Read More Read More» Feature Wanted: Crime-solving bacteria and body odor BY Meghan Rosen, Aug 26, 2015 02:32 pm Forensic investigators are moving past old-school sleuthing to analyze microbes and odors that tell a more complete story, while pursuing ways to enhance traditional tools as well. Read More Read More» More Headlines from Science News News Twin pandas look forward to growth spurts The surviving panda twin born at the National Zoo last weekend will undergo DNA tests to discover paternity. Read More By Meghan Rosen, Aug 26, 2015 12:43 pm Wild Things A world of mammal diversity has been lost because of humans Humans have eradicated large mammal biodiversity in most regions of the globe, a new study finds. Read More By Sarah Zielinski, Aug 26, 2015 09:55 am Science Ticker Virus closely related to hepatitis A discovered in seals Scientists have discovered a relative of the hepatitis A virus in seals. Read More By Sarah Schwartz, Aug 25, 2015 10:17 am News Hurricane’s tiny earthquakes could help forecasters Hurricane Sandy set off small earthquakes under its eye as it moved up the U.S. East Coast in 2012. The tiny tremors could help researchers track the behavior of future storms, researchers propose. Read More By Thomas Sumner, Aug 25, 2015 08:00 am Science Visualized Long-tongued fly sips from afar Long-tongued flies can dabble in shallow blossoms or reach into flowers with roomier nectar tubes. Read More By Susan Milius, Aug 25, 2015 07:00 am Science Ticker Chimps keep numbers high as forest losses mount African apes show surprising resilience in face of forest destruction. Read More By Bruce Bower, Aug 24, 2015 08:00 pm Science Ticker Flyby of Dione yields stunning pictures of icy Saturn moon Saturn’s moon Dione shows off its ripping landscapes during the Cassini spacecraft’s final flyby. Read More By Christopher Crockett, Aug 24, 2015 05:09 pm Privacy Policy | Update Email Preferences | Unsubscribe from All SSP Newsletters | Contact Us Facebook | Twitter | Vimeo | Google+ Society for Science & the Public • 1719 N Street, N.W. Washington, DC 20036 • Copyright © 2015

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Sci Transl Med Table of Contents for 26 August 2015; Vol. 7, No. 302

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Sponsored by Science Translational Medicine Science Translational Medicine Table of Contents   08/26/15 Volume 7, Issue 302 <!– Did you miss?… FOCUS: Single-cell analysis of cancer evolution –> Join Science Translational Medicine at ITMAT 2015 Systems Pharmacology and Translational Therapeutics in Philadelphia, PA. Oct 12-13 <!– Last chance to register for Bridging Biomedical Worlds “From Neural Circuitry to Neurotechnology” in Tokyo. –> <!– Science Translational Medicine welcomes our 2015 Associate Scientific Advisors. –> <!– The focus of this week’s issue is cancer to coincide with the AACR annual meeting –> In this week’s issue: Research Articles CANCER Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer Isaac Garcia-Murillas et al. Noninvasive mutation tracking in plasma can detect circulating tumor DNA arising from residual micrometastatic disease and thus identify patients at high risk of recurrence. SPINAL CORD INJURY Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates Lucia Friedli et al. Fundamental differences in the anatomy and function of the corticospinal tract support enhanced recovery of leg and hand function after lateralized spinal cord injury in primates compared to rodents, emphasizing the importance of primate models for spinal cord repair therapies. HUMAN IMMUNOLOGY IgH sequences in common variable immune deficiency reveal altered B cell development and selection Krishna M. Roskin et al. Deep sequence analysis of the IgH repertoires of common variable immune deficiency patients highlights phenotypic features of the disorder and potential disease mechanisms. CANCER A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo Laura R. Saunders et al. Targeting DLL3 with an antibody-drug conjugate eliminates tumor-initiating cells in high-grade pulmonary neuroendocrine cancers. Editorial FUNDING Trauma research—A field without a home base Sudha Jayaraman and Sten H. Vermund Trauma research can be a cost-effective investment worthy of attention and emphasis from the U.S. National Institutes of Health. Focus DIAGNOSTICS Does molecular monitoring matter in early-stage breast cancer? Tilak K. Sundaresan and Daniel A. Haber Serial monitoring of circulating tumor DNA predicts recurrence after surgery for localized breast cancer (Garcia-Murillas et al., this issue). Podcast CANCER Science Translational Medicine Podcast: 26 August 2015 Scott J. Dylla and Annalisa M. VanHook Scott Dylla discusses a new antibody-drug conjugate that may be effective in treating high-grade pulmonary neuroendocrine cancers. Editors’ Choice NEUROPSYCHIATRIC DISEASE Inheritance of fear and trauma Kristen Brennand Holocaust survivors and their adult offspring show differences in DNA methylation, indicating that the effects of trauma can be passed down from human parents to their offspring. CANCER Fight fire with fire Grzegorz Nalepa A new drug kills cancer cells by hyperactivating oncogenes. REGENERATIVE MEDICINE A soothing MSC-based ulcer treatment Giovanni Traverso Targeting MSCs to regions of the gut containing ulcers enables mucosal healing in a VEGF-dependent manner. Infectious disease Passenger mutations: Backseat drivers in failed translation Taia T. Wang Nearly all 129-derived mouse strains carry passenger mutations with potential phenotypic consequences.     Also Online: Current Issue Archives About the Journal Information for Authors Recommend to Your Library Sponsored by Science Translational Medicine

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I want to be in your bed

Send me a F#ckFriends request so we can hook up My usename is MyAngel094 my profile is here ONLINE NOW

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A fusion breakthrough, death metal in ancient oceans, & more

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Latest News and Headlines 25 August 2015

Death metal in ancient oceans

Exclusive: Secretive fusion company claims reactor breakthrough

How does the new ‘female Viagra’ work?

QA: How the Franco dictatorship destroyed Spanish science

Is a universal flu vaccine on the horizon?

The cancer therapy breakthrough that gives President Carter hope

Top stories: ‘Superpredator’ humans, ending chimpanzee research, and smashing the superconductivity record

Podcast: ‘Superpredator’ humans, Neolithic massacres, and more

New electric storage material could put more zip in your Tesla

Saturn’s moon has a fluffy heart

Soviet-era timber litters Arctic shores

Designer material clears hurdle for turning carbon dioxide into fuel

Tiny fountain of atoms sparks big insights into dark energy

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Re: hungry for a f&ck friend

Send me a F#ckFriends request so we can hook up My usename is Fluffy931 my profile is here SPEAK SOON

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Science Signaling Table of Contents for 25 August 2015; Volume 8, Issue 391

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Sponsored by Cell Signaling Technology, Inc. Science Signaling Table of Contents   08/25/15 Volume 8, Issue 391 <!––> Get a personal subscription and access Science Signaling on all your personal devices. AAAS members get a 65% discount! <!– –> In this week’s issue: Research Articles Protein Signaling The G protein α subunit variant XLαs promotes inositol 1,4,5-trisphosphate signaling and mediates the renal actions of parathyroid hormone in vivo Qing He et al. The extra-large Gα subunit that mediates the effects of parathyroid hormone on the kidney stimulates two distinct downstream pathways. Physiology RelB/p52-mediated NF-κB signaling alters histone acetylation to increase the abundance of corticotropin-releasing hormone in human placenta Valeria Di Stefano et al. Glucocorticoids epigenetically induce the expression of a stress hormone gene associated with labor in human placenta cells. Inflammation Extracellular signal–regulated kinase 5 promotes acute cellular and systemic inflammation Kevin Wilhelmsen et al. Inhibition of the mitogen-activated protein kinase ERK5 reduces systemic inflammation in mice. Podcasts Physiology Science Signaling Podcast: 25 August 2015 Todd Rosen et al. A glucocorticoid-mediated epigenetic switch promotes placental production of a stress hormone associated with labor. Editors’ Choice Cancer Our AIM is 2 prevent cancer Wei Wong AIM2 suppresses colorectal tumorigenesis through mechanisms that do not involve inflammasome activation. Cancer Cytokine loops promote breast cancer Leslie K. Ferrarelli Blocking autocrine cytokine loops may suppress the growth of HER2-positive breast cancer. Wnt Signaling Wnt to YAP pathway Nancy R. Gough Wnt signals through G proteins to activate the transcriptional coregulators YAP and TAZ. Cell Biology Membrane potential regulates growth L. Bryan Ray Changing the voltage across the plasma membrane causes clustering of a small guanosine triphosphatase. Cell Biology Ajuba links mechanical tension to cell cycle reentry Annalisa M. VanHook Tissue damage stimulates quiescent cells to reenter the cell cycle through a mechanism that relies on Ajuba-dependent mechanical stimulation of Yorkie activity. Physiology Hypoxia induces mitochondrial protein misfolding Annalisa M. VanHook Activation of the mitochondrial unfolded protein response protects against hypoxia-induced injury. Cancer Fat fibrosis and breast cancer Megan Frisk Obesity leads to fibrosis-mediated stiffness of mammary adipose tissue that promotes breast tumor malignancy. Medicine A tale of two asthmas Angela Colmone Concurrent blockade of IL-13 and IL-17A may improve control of asthma. Plant Biology Immune signals shape root communities Pamela J. Hines Bacteria that are endosymbiotic with the plant root respond to changes in the plant’s signaling status. Microbiology Keeping gene transcription in check Guy Riddihough A regulatory protein factor in bacteria ensures that RNA polymerase stays switched off until it receives the signal to go. Plant Biology Germination signals illuminated Pamela J. Hines The parasitic weed Striga has given up the secret of its key receptor. Also Online: Current Issue Archives About Science Signaling Information for Authors Recommend to Your Library Sponsored by Cell Signaling Technology, Inc.

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A universal flu vaccine, the new ‘female Viagra’ & more

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Latest News and Headlines 24 August 2015

How does the new ‘female Viagra’ work?

QA: How the Franco dictatorship destroyed Spanish science

Is a universal flu vaccine on the horizon?

The cancer therapy breakthrough that gives President Carter hope

Top stories: ‘Superpredator’ humans, ending chimpanzee research, and smashing the superconductivity record

Podcast: ‘Superpredator’ humans, Neolithic massacres, and more

New electric storage material could put more zip in your Tesla

Saturn’s moon has a fluffy heart

Soviet-era timber litters Arctic shores

Designer material clears hurdle for turning carbon dioxide into fuel

Tiny fountain of atoms sparks big insights into dark energy

Threats impacting forest health

Feature: Revealing the hidden dangers of dietary supplements

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Latest from Science News: Chimps keep numbers high as forest losses mount

Latest from Science News 08/25/2015 View in browser Become a Subscribing Member» Science Ticker Chimps keep numbers high as forest losses mount BY Bruce Bower, Aug 24, 2015 08:00 pm African apes show surprising resilience in face of forest destruction. Read More Read More» Science Ticker Flyby of Dione yields stunning pictures of icy Saturn moon BY Christopher Crockett, Aug 24, 2015 05:09 pm Saturn’s moon Dione shows off its ripping landscapes during the Cassini spacecraft’s final flyby. Read More Read More» News Physicists get answers from computer that didn’t run BY Andrew Grant, Aug 24, 2015 02:00 pm By exploiting the quirks of quantum mechanics, physicists consistently determined what a quantum computer would have done without actually running the computer. Read More Read More» More Headlines from Science News Reviews & Previews A naturalist recounts birds’ lives in the Scottish Highlands In Gods of the Morning, a naturalist chronicles how birds and other wildlife withstand the changing seasons in the Scottish Highlands Read More By Sid Perkins, Aug 23, 2015 09:00 am News Katrina’s legacy: Refining hurricane forecasting Ten years following Hurricane Katrina’s formation, the storm’s devastating legacy in New Orleans and beyond continues to drive storm forecast improvements. Read More By Thomas Sumner, Aug 23, 2015 05:30 am Reviews & Previews ‘Prehistoric Predators’ is a carnival of ancient dinosaurs, mammals and more A new children’s book offers gorgeous illustrations and information for everyone about ancient carnivores. Read More By Bethany Brookshire, Aug 22, 2015 09:00 am Culture Beaker A bot, not a Kardashian, probably wrote that e-cig tweet Some 80 percent of recent e-cigarette-related tweets were promotional in nature, raising concerns that the positive spin is targeting a young audience. Read More By Rachel Ehrenberg, Aug 21, 2015 04:30 pm News Extinction in lab bottle was a fluke, experiment finds Extinction in a bottle was a random catastrophe, not survival of the fittest. Read More By Tina Hesman Saey, Aug 21, 2015 01:00 pm Introducing Millions of dollars’ worth of gold and silver found beneath volcanoes A jackpot of dissolved gold and silver discovered in reservoirs of hot water beneath New Zealand’s Taupo Volcanic Zone. Read More By Thomas Sumner, Aug 21, 2015 12:03 pm How Bizarre Whistled language uses both sides of the brain Unlike spoken words, language made of whistles processed by both sides of the brain. Read More By Laura Sanders, Aug 21, 2015 11:45 am Privacy Policy | Update Email Preferences | Unsubscribe from All SSP Newsletters | Contact Us Facebook | Twitter | Vimeo | Google+ Society for Science & the Public • 1719 N Street, N.W. Washington, DC 20036 • Copyright © 2015

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